Overview

  • Product name

    Anti-GPCR G2A antibody - Extracellular domain
    See all GPCR G2A primary antibodies
  • Description

    Rabbit polyclonal to GPCR G2A - Extracellular domain
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except PRDM4 (61%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey, Gorilla
  • Immunogen

    Synthetic peptide, corresponding to 18 amino acids from the 3rd extracellular domain of Human GPCR G2A (NP_037477.1).

  • Positive control

    • Human spleen tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab150509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 28 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.
  • Tissue specificity

    Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.
  • Information by UniProt
  • Database links

  • Alternative names

    • G Protein Coupled Receptor G2A antibody
    • G2 accumulation protein antibody
    • G2A antibody
    • GP132_HUMAN antibody
    • GPR132 antibody
    • Probable G-protein coupled receptor 132 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labeling GPCR G2A with ab150509 at 28 µg/ml.

References

ab150509 has not yet been referenced specifically in any publications.

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