Overview

  • Product name

  • Description

    Rabbit polyclonal to GPCR GPR120
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human GPCR GPR120 aa 226-284. Synthetic peptide around Val 259.
    Database link: Q5NUL3

  • Positive control

    • IHC-P: Human testis tissue. WB: HEK-293T, Raw 264.7 and PC-12 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab230869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200.
WB 1/500 - 1/1000. Predicted molecular weight: 42 kDa.

Target

  • Function

    Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
  • Tissue specificity

    Abundant expression in the intestinal tract.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    Phosphorylated. FFA stimulation facilitates phosphorylation.
  • Cellular localization

    Cell membrane. Colocalized with ARRB2 following DHA treatment.
  • Information by UniProt
  • Database links

  • Alternative names

    • BMIQ10 antibody
    • FFAR4 antibody
    • Free fatty acid receptor 4 antibody
    • G protein coupled receptor 120 antibody
    • G protein coupled receptor 129 antibody
    • G protein coupled receptor GT01 antibody
    • G protein coupled receptor PGR 4 antibody
    • G protein coupled receptor PGR4 antibody
    • G-protein coupled receptor 120 antibody
    • G-protein coupled receptor 129 antibody
    • G-protein coupled receptor GT01 antibody
    • G-protein coupled receptor PGR4 antibody
    • GPR 120 antibody
    • GPR 129 antibody
    • GPR120 antibody
    • GPR129 antibody
    • GT01 antibody
    • HGNC:19345 antibody
    • MGC119984 antibody
    • O3FA1_HUMAN antibody
    • O3FAR1 antibody
    • Omega-3 fatty acid receptor 1 antibody
    • PGR 4 antibody
    • PGR4 antibody
    see all

Images

  • All lanes : Anti-GPCR GPR120 antibody (ab230869) at 1/500 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate.
    Lane 2 : Raw 264.7 (mouse macrophage cell line transformed with Abelson murine leukemia virus) whole cell lysate.
    Lane 3 : PC-12 (rat adrenal gland pheochromocytoma cell line) whole cell lysate.

    Predicted band size: 42 kDa

  • Formalin-fixed, paraffin-embeddedhuman testis tissue stained for GPCR GPR120 using ab230869 at 1/200 dilution in immunohistochemical analysis.

References

ab230869 has not yet been referenced specifically in any publications.

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