Anti-GPCR GPR124 antibody (ab67280)
Key features and details
- Rabbit polyclonal to GPCR GPR124
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
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Product name
Anti-GPCR GPR124 antibody
See all GPCR GPR124 primary antibodies -
Description
Rabbit polyclonal to GPCR GPR124 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Synthetic peptide (Human) of 14 amino acids from the central region
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Positive control
- WB: Rat Kidney Tissue Lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab67280 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 180 kDa (predicted molecular weight: 142 kDa).
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Notes |
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WB
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 180 kDa (predicted molecular weight: 142 kDa). |
Target
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Function
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. -
Tissue specificity
Expressed in endothelial cells (at protein level). Abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. -
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain. -
Domain
Binds to DLG1 through its PDZ-binding motif. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
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Alternative names
- DKFZp434C211 antibody
- DKFZp434J0911 antibody
- FLJ14390 antibody
see all
Images
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Lane 1 : Anti-GPCR GPR124 antibody (ab67280) at 2 µg/ml
Lane 2 : Anti-GPCR GPR124 antibody (ab67280) at 4 µg/ml
All lanes : Rat kidney tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 142 kDa
Observed band size: 176,180 kDa why is the actual band size different from the predicted?
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab67280 has been referenced in 1 publication.
- Wang Z et al. ß-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. Oncol Lett 16:2143-2150 (2018). PubMed: 30008912