Anti-GPCR GPR126 antibody (ab117092)
Key features and details
- Rabbit polyclonal to GPCR GPR126
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GPCR GPR126 antibody
See all GPCR GPR126 primary antibodies -
Description
Rabbit polyclonal to GPCR GPR126 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide conjugated to KLH, from the N terminal domain of Human GPCR GPR126.
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Positive control
- Human liver and prostate tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab117092 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
Use a concentration of 10 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
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Notes |
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IHC-P
Use a concentration of 10 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K. |
Target
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Function
Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. -
Tissue specificity
Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. -
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 CUB domain.
Contains 1 GPS domain.
Contains 1 pentaxin domain. -
Post-translational
modificationsProteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. -
Cellular localization
Cell membrane. Detected on the cell surface of activated but not resting umbilical vein. - Information by UniProt
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Database links
- Entrez Gene: 57211 Human
- Entrez Gene: 215798 Mouse
- Omim: 612243 Human
- SwissProt: Q86SQ4 Human
- SwissProt: Q6F3F9 Mouse
- Unigene: 726094 Human
- Unigene: 440142 Mouse
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Alternative names
- adhesion G protein coupled receptor G6 antibody
- APG1 antibody
- Developmentally regulated G protein coupled receptor antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab117092 has been referenced in 2 publications.
- Liu Z et al. An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment. Elife 10:N/A (2021). PubMed: 34318745
- Wu S et al. Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer. Nat Commun 10:720 (2019). PubMed: 30755618