Key features and details
- Rabbit polyclonal to GPCR GPR126
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-GPCR GPR126 antibody
See all GPCR GPR126 primary antibodies
DescriptionRabbit polyclonal to GPCR GPR126
SpecificityBLAST analysis of the peptide immunogen showed no homology with other human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Cow, Monkey, Gorilla, Common marmoset
Synthetic peptide corresponding to Human GPCR GPR126 (internal sequence). Synthetic peptide, corresponding to 18 amino acids from internal region of Human GPCR GPR126.
Database link: Q86SQ4
- Human lung (respiratory epithelium) tissue and human liver tissue.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab150562 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 10 µg/ml. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. Perform Proteinase K antigen retrieval.|
FunctionOrphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.
Tissue specificityExpressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
Sequence similaritiesBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 CUB domain.
Contains 1 GPS domain.
Contains 1 pentaxin domain.
modificationsProteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
Cellular localizationCell membrane. Detected on the cell surface of activated but not resting umbilical vein.
- Information by UniProt
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ab150562 has not yet been referenced specifically in any publications.