• Product name
  • Description
    Rabbit polyclonal to GPCR GPR126
  • Host species
  • Specificity
    Detects endogenous levels of total GPCR GPR126 protein.
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal region of human GPCR GPR126

  • Positive control
    • Extracts from HUVEC cells


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS

    Without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab75356 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 137 kDa (predicted molecular weight: 137 kDa).
ELISA 1/5000.


  • Function
    Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels.
  • Tissue specificity
    Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 1 CUB domain.
    Contains 1 GPS domain.
    Contains 1 pentaxin domain.
  • Post-translational
    Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.
  • Cellular localization
    Cell membrane. Detected on the cell surface of activated but not resting umbilical vein.
  • Information by UniProt
  • Database links
  • Alternative names
    • adhesion G protein coupled receptor G6 antibody
    • APG1 antibody
    • Developmentally regulated G protein coupled receptor antibody
    • Developmentally regulated G-protein-coupled receptor antibody
    • dj287g14.2 antibody
    • DREG antibody
    • G protein coupled receptor 126 antibody
    • G-protein coupled receptor 126 antibody
    • GP126_HUMAN antibody
    • GPR126 antibody
    • HBV PreS1 transactivated protein 2 antibody
    • HBV PreS1-transactivated protein 2 antibody
    • LCCS9 antibody
    • OTTHUMP00000017320 antibody
    • OTTHUMP00000237093 antibody
    • OTTHUMP00000237094 antibody
    • OTTHUMP00000237115 antibody
    • PR126 antibody
    • Probable G protein coupled receptor 126 [Precursor] antibody
    • Probable G protein coupled receptor 126 antibody
    • Probable G-protein coupled receptor 126 [Precursor] antibody
    • Probable G-protein coupled receptor 126 antibody
    • PS1TP2 antibody
    • Vascular inducible G protein coupled receptor antibody
    • Vascular inducible G protein-coupled receptor antibody
    • VIGR antibody
    see all


  • All lanes : Anti-GPCR GPR126 antibody (ab75356) at 1/500 dilution

    Lane 1 : extracts from HUVEC cells
    Lane 2 : extracts from HUVEC cells with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 137 kDa
    Observed band size: 137 kDa


This product has been referenced in:
  • Kitagaki J  et al. A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population. PLoS One 11:e0160765 (2016). WB . Read more (PubMed: 27509131) »
  • Cui H  et al. GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling. J Biol Chem 289:34871-85 (2014). Read more (PubMed: 25217645) »

See all 2 Publications for this product

Customer reviews and Q&As

The antibody has not been predicted to cross react with mouse GPR126. The lab aligned the exact immunogenic sequence used to raise the antibody with Q6F3F9, and the homology is only 64.3%.

We usually say that a homology of 85% or higher h...

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Thank you for this feedback. I am sorry that I could not be of more help on this occasion. If you like to get some more information on our testing discount program, please find the Terms and Conditions of this offer at: www.abcam.com/collabora...

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Thank you for contacting us. I am happy to let you know the following immunogen sequences: ab65175: xxxxxxxxxxxxxxxxxx ab75356: yyyyyyyyyyyyyyyy In preliminary searches, I could not find conclusive matches for these peptides in zebrafish (onl...

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