Overview

  • Product name

    Anti-GPCR GPR35 antibody - Cytoplasmic domain
    See all GPCR GPR35 primary antibodies
  • Description

    Rabbit polyclonal to GPCR GPR35 - Cytoplasmic domain
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide within Human GPCR GPR35. The exact sequence is proprietary. Synthetic 19 amino acid peptide from 3rd cytoplasmic domain.
    Database link: Q9HC97

  • Positive control

    • Human pancreas tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
IHC-P Use a concentration of 5 - 9 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance

    G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GPR35 is a member of this family and is an orphan receptor. GPR35 expression was reported only in rat intestine (O'Dowd et al., 1998) by Northern hybridization; however, another study showed that GPR35 is expressed widely, including pancreatic islets and skeletal muscle, with higher levels in adult lung, small intestine, colon, and stomach.
  • Cellular localization

    Cell membrane; Multi-pass membrane protein
  • Database links

  • Alternative names

    • G protein coupled receptor 35 antibody
    • G protein coupled receptor 35 antibody
    • GPR 35 antibody
    • GPR35 antibody
    • KYNA receptor antibody
    • Kynurenic acid receptor antibody
    • Probable G protein coupled receptor 35 antibody
    • Probable G protein coupled receptor GPR35 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human pancreas tissue labeling GPCR GPR35 using ab188949 at 9 µg/mL.

References

ab188949 has not yet been referenced specifically in any publications.

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