Anti-GPCR GPR37 antibody - N-terminal (ab188928)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-GPCR GPR37 antibody - N-terminal
See all GPCR GPR37 primary antibodies -
Description
Rabbit polyclonal to GPCR GPR37 - N-terminal -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Monkey, Gorilla, Common marmoset
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Immunogen
Synthetic peptide within Human GPCR GPR37 (N terminal). The exact sequence is proprietary. synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPCR GPR37
Database link: O15354 -
Positive control
- Human brain tissue
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab188928 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Orphan receptor. May have a unique functional role in the central nervous system. -
Tissue specificity
Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsUbiquitinated by PARK2 in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. -
Cellular localization
Cell membrane. Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 2861 Human
- Entrez Gene: 14763 Mouse
- Entrez Gene: 117549 Rat
- Omim: 602583 Human
- SwissProt: O15354 Human
- SwissProt: Q9QY42 Mouse
- SwissProt: Q9QYC6 Rat
- Unigene: 731392 Human
see all -
Alternative names
- EDNRBL antibody
- Endothelin B receptor like protein 1 antibody
- Endothelin B receptor-like protein 1 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR37 antibody - N-terminal (ab188928)Immunohistochemical staining of Human brain (neuron and glia) tissue labeling GPCR GPR37 using ab188928 at 1 µg/ml.
Protocols
References
ab188928 has not yet been referenced specifically in any publications.
