Overview

  • Product name

  • Description

    Rabbit polyclonal to GPCR GPR55
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cyt, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human GPCR GPR55 aa 159-180 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    FHGKVEKYMCFHNMSDDTWSAK


    Database link: Q9Y2T6

  • Positive control

    • Rat brain tissue; mouse brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab203663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/20 - 1/100.
IHC-P 1/100 - 1/500.

(or 1/50 - 1/200 using a fluorescent secondary antibody).

WB 1/100 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).

Target

  • Function

    May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.
  • Tissue specificity

    Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • G protein coupled receptor 55 antibody
    • G-protein coupled receptor 55 antibody
    • GPCR GPR55 antibody
    • GPR 55 antibody
    • Gpr55 antibody
    • GPR55_HUMAN antibody
    • LPIR1 antibody
    • Probable G protein coupled receptor 55 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling GPCR GPR55 with ab203663 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • All lanes : Anti-GPCR GPR55 antibody (ab203663) at 1/200 dilution

    Lane 1 : Mouse brain lysate
    Lane 2 : Mouse embryo lysate

    Secondary
    All lanes : Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/3000 dilution

    Predicted band size: 37 kDa
    Observed band size: 37 kDa

References

This product has been referenced in:

  • Shi QX  et al. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Mol Brain 10:38 (2017). WB, IHC-FoFr ; Mouse . Read more (PubMed: 28800762) »
See 1 Publication for this product

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