Overview

  • Product name

  • Description

    Rabbit polyclonal to GPCR MRGX2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 286-316 of Human GPCR MRGX2 (NP_473371.1, Q96LB1).

  • Positive control

    • 293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab129548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

Target

  • Function

    Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
  • Tissue specificity

    Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • G protein coupled receptor MRGX 2 antibody
    • G protein coupled receptor MRGX2 antibody
    • Mas related G protein coupled receptor member X2 antibody
    • Mas related gene MRGX 2 antibody
    • Mas related gene MRGX2 antibody
    • MAS related GPR member X2 antibody
    • Mas-related G-protein coupled receptor member X antibody
    • Mas-related G-protein coupled receptor member X2 antibody
    • MRGPRX 2 antibody
    • MRGPRX2 antibody
    • MRGX 2 antibody
    • MRGX2 antibody
    • MRGX2_HUMAN antibody
    see all

Images

  • Anti-GPCR MRGX2 antibody (ab129548) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size: 37 kDa

References

This product has been referenced in:

  • Murakami T  et al. MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells. Mol Med Rep 18:4951-4959 (2018). Read more (PubMed: 30280189) »
See 1 Publication for this product

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