Anti-GPCR RDC1/CXCR-7 antibody (ab38089)
Key features and details
- Rabbit polyclonal to GPCR RDC1/CXCR-7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-GPCR RDC1/CXCR-7 antibody
See all GPCR RDC1/CXCR-7 primary antibodies -
Description
Rabbit polyclonal to GPCR RDC1/CXCR-7 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human GPCR RDC1/CXCR-7 aa 1-100 conjugated to keyhole limpet haemocyanin.
(Peptide available asab38088) -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab38089 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
1/250. Detects a band of approximately 52 kDa (predicted molecular weight: 42 kDa).Can be blocked with Human GPCR RDC1/CXCR-7 peptide (ab38088).
GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE. |
Notes |
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WB
1/250. Detects a band of approximately 52 kDa (predicted molecular weight: 42 kDa).Can be blocked with Human GPCR RDC1/CXCR-7 peptide (ab38088). GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE. |
Target
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Function
Receptor for CXCL12/SDF1. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. -
Tissue specificity
Expressed in monocytes, basophils, and B-cells. Lower expression in CD4+ T-lymphocytes and natural killer cells. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 57007 Human
- Entrez Gene: 12778 Mouse
- Omim: 610376 Human
- SwissProt: P25106 Human
- SwissProt: P56485 Mouse
- Unigene: 471751 Human
- Unigene: 6522 Mouse
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Alternative names
- ACKR3 antibody
- atypical chemokine receptor 3 antibody
- C X C chemokine receptor type 7 antibody
see all
Images
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All lanes : Anti-GPCR RDC1/CXCR-7 antibody (ab38089) at 1/250 dilution
Lane 1 : Human Brain Tissue Lysate
Lane 2 : Human Testis Tissue Lysate
Lane 3 : Human Liver Tissue Lysate
Lane 4 : Human Heart Tissue Lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : IRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 42 kDa
Observed band size: 52 kDa why is the actual band size different from the predicted?
GPCR RCD1 is glycosylated so it is not unexpected that it runs higher than predicted (based on primary structure) in SDS PAGE.
Datasheets and documents
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SDS download
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Datasheet download
References (25)
ab38089 has been referenced in 25 publications.
- Joo M et al. Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression in vitro. Oncol Rep 47:N/A (2022). PubMed: 34958113
- Zhang J et al. SOX4 promotes the growth and metastasis of breast cancer. Cancer Cell Int 20:468 (2020). PubMed: 33005101
- Bai Y et al. RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis. Theranostics 9:3459-3475 (2019). PubMed: 31281490
- Kim N et al. CXCR7 promotes migration and invasion in head and neck squamous cell carcinoma by upregulating TGF-ß1/Smad2/3 signaling. Sci Rep 9:18100 (2019). PubMed: 31792315
- Zhang L et al. Cytokine augments the sorafenib-induced apoptosis in Huh7 liver cancer cell by inducing mitochondrial fragmentation and activating MAPK-JNK signalling pathway. Biomed Pharmacother 110:213-223 (2019). PubMed: 30476722