Overview

  • Product name

    Anti-GPCR TGR7 antibody - Cytoplasmic domain
    See all GPCR TGR7 primary antibodies
  • Description

    Rabbit polyclonal to GPCR TGR7 - Cytoplasmic domain
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Gorilla
  • Immunogen

    Synthetic peptide within Human GPCR TGR7. The exact sequence is proprietary. The peptide corresponds to 18 amino acids from the 4th cytoplasmic domain. (NP_944605.2)
    Database link: Q8TDS7

  • Positive control

    • Human brain, medulla, tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab189006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Cellular localization

    Cell membrane. Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beta alanine receptor antibody
    • Beta-alanine receptor antibody
    • G protein coupled receptor TGR7 antibody
    • G-protein coupled receptor TGR7 antibody
    • mas related G protein coupled MRGD antibody
    • Mas related G protein coupled receptor member D antibody
    • MAS related GPR member D antibody
    • Mas-related G-protein coupled receptor member D antibody
    • MRGD antibody
    • Mrgprd antibody
    • MRGRD_HUMAN antibody
    • TGR7 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded, formalin-fixed Human brain, medulla, tissue labeling GPCR TGR7 using ab189006 at 10 µg/ml.

References

ab189006 has not yet been referenced specifically in any publications.

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