Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab218717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-GPCR TGR7 antibody [EPR10597] (ab155099)

  • Form

    Lyophilised
  • Additional notes

    Reconstitution instructions:

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.

    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.

    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.

    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.

    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • Beta alanine receptor
    • Beta-alanine receptor
    • G protein coupled receptor TGR7
    • G-protein coupled receptor TGR7
    • mas related G protein coupled MRGD
    • Mas related G protein coupled receptor member D
    • MAS related GPR member D
    • Mas-related G-protein coupled receptor member D
    • MRGD
    • Mrgprd
    • MRGRD_HUMAN
    • TGR7
    see all
  • Function

    May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Cellular localization

    Cell membrane. Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
  • Information by UniProt

References

ab218717 has not yet been referenced specifically in any publications.

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