GppCp (GMPPCP), Nonhydrolyzable GTP analog (ab146660)

Overview

  • Product name

    GppCp (GMPPCP), Nonhydrolyzable GTP analog
  • Description

    Nonhydrolyzable GTP analog
  • Alternative names

    • GMPPCP
  • Biological description

    Nonhydrolyzable GTP analog. Modulates G-protein cell signaling, protein synthesis and other metabolic processes. Forms stable protein complexes.
  • Purity

    > 95%
  • CAS Number

    10470-57-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    521.21
  • Molecular formula

    C11H18N5O13P3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Shepotinovskaya IV  et al. Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY. Acta Crystallogr D Biol Crystallogr 59:1834-7 (2003). Read more (PubMed: 14501130) »
  • Schweins T  et al. The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J Mol Biol 266:847-56 (1997). Read more (PubMed: 9102473) »
  • Dye RB & Williams RC Assembly of microtubules from tubulin bearing the nonhydrolyzable guanosine triphosphate analogue GMPPCP [guanylyl 5'-(beta, gamma-methylenediphosphonate)]: variability of growth rates and the hydrolysis of GTP. Biochemistry 35:14331-9 (1996). Read more (PubMed: 8916920) »

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