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GppNHp, Non-hydrolyzable GTP analog (ab146659)

  • Datasheet
  • SDS
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Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659)

    Key features and details

    • Non-hydrolyzable GTP analog
    • CAS Number: 64564-03-0
    • Purity: > 95%
    • Soluble in water to 75 mM

    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      GppNHp, Non-hydrolyzable GTP analog
    • Description

      Non-hydrolyzable GTP analog
    • Biological description

      Non-hydrolyzable GTP analog. Has an amine group in place of an oxygen atom. Potent adenylate cyclase stimulator. Binds tightly to G-protein in the presence of Mg2+. Forms stable Ras complexes.
    • Purity

      > 95%
    • CAS Number

      64564-03-0
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      [[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate tetralithium

    • Molecular weight

      545.93
    • Molecular formula

      C10H13Li4N6O13P3
    • PubChem identifier

      136494784
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 75 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N
    • Source

      Synthetic

    Associated products

      Images

      • Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659)
        Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659)
        2D chemical structure image of ab146659, GppNHp, Non-hydrolyzable GTP analog

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (6)

      Publishing research using ab146659? Please let us know so that we can cite the reference in this datasheet.

      ab146659 has been referenced in 6 publications.

      • Lattao R  et al. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins. Dev Cell N/A:N/A (2021). PubMed: 33725482
      • Kutsch M  et al. Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. EMBO J 39:e104926 (2020). PubMed: 32510692
      • English JG  et al. VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell 178:748-761.e17 (2019). PubMed: 31280962
      • Kanie T & Jackson PK Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP. Bio Protoc 8:N/A (2018). PubMed: 29951569
      • Ivanova AA  et al. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). J Biol Chem 292:11091-11108 (2017). PubMed: 28487361
      • Kanie T  et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell 42:22-36.e12 (2017). PubMed: 28625565

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