Overview

  • Product name

    Anti-GPR56 antibody - N-terminal
    See all GPR56 primary antibodies
  • Description

    Rabbit polyclonal to GPR56 - N-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except MACF1 (44%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide within Human GPR56 aa 75-125 (extracellular). The exact sequence is proprietary. 18 amino acid peptide from N terminal extracellular domain.
    Database link: Q9Y653

  • Positive control

    • Human prostate tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 7.5 - 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Could be involved in cell-cell interactions.
  • Tissue specificity

    Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells.
  • Involvement in disease

    Polymicrogyria, bilateral frontoparietal (BFPP) [MIM:606854]: A malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination, most severe in the frontoparietal regions. BFPP clinical manifestations include developmental and psychomotor delay, cerebellar and pyramidal signs, truncal ataxia, seizures, hyperreflexia. Polymicrogyria is a heterogeneous disorder, considered to be the result of postmigratory abnormal cortical organization. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 1 GPS domain.
  • Post-translational
    modifications

    The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 7 transmembrane protein with no EGF like N terminal domains 1 antibody
    • BFPP antibody
    • DKFZp781L1398 antibody
    • EGF TM7 like antibody
    • G protein coupled receptor 56 antibody
    • G-protein coupled receptor 56 antibody
    • GPR 56 antibody
    • Gpr56 antibody
    • GPR56_HUMAN antibody
    • Polymicrogyria bilateral frontoparietal antibody
    • Protein TM7XN1 antibody
    • TM7LN4 antibody
    • TM7XN1 antibody
    • TM7XN1 protein antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate tissue, labeling GPR56 with ab188969 at 10 µg/ml.

References

ab188969 has not yet been referenced specifically in any publications.

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