Overview

  • Product name

  • Description

    Rabbit polyclonal to GPRC5A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Hamster, Monkey, Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human GPRC5A (C terminal).
    Database link: NP_003970.1

  • Positive control

    • Human brain neuron and testis tissues.
  • General notes

     This product was previously labelled as RAI3

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab140770 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC Use at an assay dependent concentration.

Target

  • Function

    Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
  • Tissue specificity

    Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 3 family.
  • Cellular localization

    Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • G protein coupled receptor family C group 5 member A antibody
    • G-protein coupled receptor family C group 5 member A antibody
    • GPCR 5A antibody
    • GPCR5A antibody
    • Gprc 5a antibody
    • Gprc5a antibody
    • Orphan G protein coupling receptor PEIG 1 antibody
    • Orphan G protein coupling receptor PEIG1 antibody
    • Orphan G-protein-coupling receptor PEIG-1 antibody
    • RAI 3 antibody
    • RAI3_HUMAN antibody
    • Raig 1 antibody
    • RAIG-1 antibody
    • Raig1 antibody
    • Retinoic acid induced 3 antibody
    • Retinoic acid induced gene 1 protein antibody
    • Retinoic acid induced protein 3 antibody
    • Retinoic acid responsive antibody
    • Retinoic acid responsive gene antibody
    • Retinoic acid-induced gene 1 protein antibody
    • Retinoic acid-induced protein 3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin embedded Human brain neuron tissue labelling GPRC5A with ab140770 at 10 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin embedded Human testis tissue labelling GPRC5A with ab140770 at 10 µg/ml.

References

ab140770 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab140770.
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