Anti-GPRC5A antibody - Extracellular domain (ab188905)
Key features and details
- Rabbit polyclonal to GPRC5A - Extracellular domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GPRC5A antibody - Extracellular domain
See all GPRC5A primary antibodies -
Description
Rabbit polyclonal to GPRC5A - Extracellular domain -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Hamster, Cow, Dog, Monkey, Gorilla -
Immunogen
Synthetic peptide corresponding to Human GPRC5A (extracellular). (16 amino acid peptide from the 2nd extracellular domain; NP_003970.1).
Database link: Q8NFJ5 -
Positive control
- Human testis and prostate tissues; GPRC5A-transfected HEK293 cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab188905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 18 - 36 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 18 - 36 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. -
Tissue specificity
Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart. -
Sequence similarities
Belongs to the G-protein coupled receptor 3 family. -
Cellular localization
Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles. - Information by UniProt
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Database links
- Entrez Gene: 516026 Cow
- Entrez Gene: 486680 Dog
- Entrez Gene: 101151750 Gorilla
- Entrez Gene: 101822388 Hamster
- Entrez Gene: 9052 Human
- Entrez Gene: 232431 Mouse
- Entrez Gene: 312790 Rat
- Omim: 604138 Human
see all -
Alternative names
- G protein coupled receptor family C group 5 member A antibody
- G-protein coupled receptor family C group 5 member A antibody
- GPCR 5A antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab188905 has not yet been referenced specifically in any publications.