Key features and details
- Potent, selective 5-HT1B/1D receptor antagonist
- CAS Number: 148642-42-6
- Purity: > 97%
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameGR 127935 hydrochloride, 5-HT1B/1D receptor antagonist
DescriptionPotent, selective 5-HT1B/1D receptor antagonist
Potent and selective 5-HT1B/1D receptor antagonist (pKi = 8.5 for both 5-HT1D in rat and 5-HT1D in guinea pig). 100-fold selectivity over 5-HT1A, 5-HT1E, and 5-HT2C. Displays centrally mediated effects upon systemic administration.
Chemical nameN-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-carboxamide hydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120523 has been referenced in 1 publication.
- Asaoka N et al. Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels. Sci Rep 7:13609 (2017). PubMed: 29051549