Anti-GRAF antibody (ab238883)

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Overview

  • Product name

    Anti-GRAF antibody
    See all GRAF primary antibodies

  • Description

    Rabbit polyclonal to GRAF

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Recombinant fragment corresponding to Human GRAF aa 625-814.
    Sequence:

    ESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLS PSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHA VFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSE LSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL


    Database link: Q9UNA1-1

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • IHC-P: Human breast cancer and colon cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab238883 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    GTPase-activating protein for RHOA and CDC42.

  • Involvement in disease

    Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.

  • Sequence similarities

    Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
    Contains 1 SH3 domain.

  • Cellular localization

    Cell junction > focal adhesion. Cytoplasm > cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures.
  • Information by UniProt

  • Database links

    • Alternative names

      • arhgap26 antibody
      • FLJ42530 antibody
      • GRAF antibody
      • GRAF1 antibody
      • GTPase regulator associated with focal adhesion kinase antibody
      • GTPase regulator associated with focal adhesion kinase pp125(FAK) antibody
      • KIAA0621 antibody
      • oligophrenin 1 like protein antibody
      • Oligophrenin-1-like protein antibody
      • oligophrenin1like protein antibody
      • OPHN1L antibody
      • OPHN1L1 antibody
      • RHG26_HUMAN antibody
      • Rho GTPase activating protein 26 antibody
      • Rho GTPase activating protein26 antibody
      • Rho GTPase-activating protein 26 antibody
      • Rho-type GTPase-activating protein 26 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRAF antibody (ab238883)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRAF antibody (ab238883)

      Paraffin-embedded human breast cancer tissue stained for GRAF with ab238883 at a 1/100 dilution in immunohistochemical analysis.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRAF antibody (ab238883)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRAF antibody (ab238883)

      Paraffin-embedded human colon cancer tissue stained for GRAF with ab238883 at a 1/100 dilution in immunohistochemical analysis.

    References

    ab238883 has not yet been referenced specifically in any publications.

    Publishing research using ab238883? Please let us know so that we can cite the reference in this datasheet.

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