Key features and details
- Cation-selective, single-filing pore forming antibiotic agent
- CAS Number: 11029-61-1
- Purity: > 90%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameGramicidin A, Antibiotic agent
DescriptionCation-selective, single-filing pore forming antibiotic agent
Biological descriptionCation-selective, single-filing pore forming antibiotic agent. Forms a membrane channel permeable to small monovalent cations, protons, and water but impermeable to divalent cations and anions. Induces K+/H+-exchange in mitochondria in a non-voltage dependent manner. Shows bactericidal effects against non-bacilli Gram-positive strains and select Gram-negative bacteria in vivo.
SequenceVGALAVVVWLWLWLW (Modification: Val-1 = HCO-Val, Leu-4 = D-leu, Val-6 = D-Val, Val-8 = D-Val, Leu-10 = D-Leu, Leu-12 = D-Leu, Leu-14 = D-Leu, Trp-15 = Trp-NHCH2CH2OH)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144510 has been referenced in 2 publications.
- Rossi A et al. Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models. Cell Rep 30:2332-2348.e10 (2020). PubMed: 32075767
- Bertholet AM et al. H+ transport is an integral function of the mitochondrial ADP/ATP carrier. Nature 571:515-520 (2019). PubMed: 31341297