• Product name

  • Description

    Rabbit polyclonal to Granulin
  • Host species

  • Tested applications

    Suitable for: WB, IPmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the C-terminal region of human Granulin.

  • Positive control

    • Human MDA-MB-231 breast adenocarcinoma, PC-3 prostate adenocarcinoma (bone metastatic site), HeLa cervical carcinoma, and HT1080 fibrosarcoma lysates.



Our Abpromise guarantee covers the use of ab53880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IP: Use at a concentration of 7 µg/reaction.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects bands varying from approximately 64-88 kDa depending on degree of protein glycosylation.(predicted molecular weight: 64 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
      Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
    • Tissue specificity

      In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
    • Involvement in disease

      Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485]; also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
    • Sequence similarities

      Belongs to the granulin family.
    • Post-translational

      Granulins are disulfide bridged.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • Acrogranin antibody
      • CLN11 antibody
      • GEP antibody
      • GP88 antibody
      • Granulin A antibody
      • Granulin B antibody
      • Granulin C antibody
      • Granulin D antibody
      • Granulin E antibody
      • Granulin epithelin antibody
      • Granulin F antibody
      • Granulin G antibody
      • Granulin-7 antibody
      • Granulins antibody
      • GRN antibody
      • GRN_HUMAN antibody
      • PC cell derived growth factor antibody
      • PCDGF antibody
      • PEPI antibody
      • PGRN antibody
      • Proepithelin antibody
      • Progranulin antibody
      see all


    • All lanes : Anti-Granulin antibody (ab53880) at 1 µg/ml

      Lane 1 : MDA-MB-231 cell lysate
      Lane 2 : PC-3 cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : HT1080 cell lysate

      Predicted band size: 64 kDa
      Observed band size: 64 kDa

      Detects bands varying from approximately 64-88 kDa depending on degree of protein glycosylation.


    ab53880 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As


    Thank you for your enquiry. I contacted the originator of ab53880 Granulin antibody who have kindly provided the following information. A BLAST search with the immunogen used for the antibody and the protein accession P28799 and below show 100% homology / alignment to all the forms of Granulin. However, I can confirm the antibody has not been specifically tested for reactivity to each of the individual Granulin forms (A-G). ]sp|P28799.2|GRN_HUMAN RecName: Full=Granulins; AltName: Full=Proepithelin; Short=PEPI; Contains: RecName: Full=Acrogranin; Contains: RecName: Full=Paragranulin; Contains: RecName: Full=Granulin-1; AltName: Full=Granulin G; Contains: RecName: Full=Granulin-2; AltName: Full=Granulin F; Contains: RecName: Full=Granulin-3; AltName: Full=Granulin B; Contains: RecName: Full=Granulin-4; AltName: Full=Granulin A; Contains: RecName: Full=Granulin-5; AltName: Full=Granulin C; Contains: RecName: Full=Granulin-6; AltName: Full=Granulin D; Contains: RecName: Full=Granulin-7; AltName: Full=Granulin E; Flags: Precursor Length=593 Score = 60.4 bits (135), Expect = 5e-15 Identities = 17/17 (100%), Positives = 17/17 (100%), Gaps = 0/17 (0%) I hope this information is helpful. Please do not hesitate to contact us again if you have any further questions.

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