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    granzyme-a-antibody-ga6-ab10870.pdf

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Cell Biology Apoptosis Extracellular Signals Granzymes
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Anti-Granzyme A antibody [GA6] (ab10870)

  • Datasheet
Reviews (1) Submit a question References (3)

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Key features and details

  • Mouse monoclonal [GA6] to Granzyme A
  • Reacts with: Human
  • Isotype: IgG1

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Protein
Recombinant human Granzyme A protein (ab157288)
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Secondary
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Overview

  • Product name

    Anti-Granzyme A antibody [GA6]
    See all Granzyme A primary antibodies
  • Description

    Mouse monoclonal [GA6] to Granzyme A
  • Host species

    Mouse
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant Granzyme A (Human).

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein A purified
  • Purification notes

    Purified IgG prepared by affinity chromatography from tissue culture supernatant.
  • Clonality

    Monoclonal
  • Clone number

    GA6
  • Myeloma

    Sp2/0
  • Isotype

    IgG1
  • Research areas

    • Cell Biology
    • Apoptosis
    • Extracellular Signals
    • Granzymes
    • Immunology
    • Adaptive Immunity
    • T Cells
    • Cytotoxic Cells
    • Immunology
    • Innate Immunity
    • NK Cells

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
  • Recombinant Protein

    • Recombinant human Granzyme A protein (ab157288)

Target

  • Function

    This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
  • Sequence similarities

    Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localization

    Secreted. Cytoplasmic granule.
  • Target information above from: UniProt accession P12544 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3001 Human
    • Omim: 140050 Human
    • SwissProt: P12544 Human
    • Unigene: 90708 Human
    • Alternative names

      • CTL tryptase antibody
      • CTLA3 antibody
      • Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody
      • Cytotoxic T lymphocyte associated serine esterase 3 antibody
      • Cytotoxic T lymphocyte proteinase 1 antibody
      • Cytotoxic T-lymphocyte proteinase 1 antibody
      • Fragmentin 1 antibody
      • Fragmentin-1 antibody
      • GRAA_HUMAN antibody
      • Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody
      • Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease) antibody
      • Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody
      • Granzyme A antibody
      • Granzyme A precursor antibody
      • Granzyme-1 antibody
      • GZMA antibody
      • H factor antibody
      • Hanukah factor serine protease antibody
      • Hanukkah factor antibody
      • HF antibody
      • HFSP antibody
      • TSP1 antibody
      see all

    Protocols

    • Immunohistochemistry protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (3)

    Publishing research using ab10870? Please let us know so that we can cite the reference in this datasheet.

    ab10870 has been referenced in 3 publications.

    • Papalampros A  et al. Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPa Expression. Cancers (Basel) 12:N/A (2020). PubMed: 32645996
    • Li H  et al. Glucocorticoid Receptor and Sequential P53 Activation by Dexamethasone Mediates Apoptosis and Cell Cycle Arrest of Osteoblastic MC3T3-E1 Cells. PLoS One 7:e37030 (2012). WB ; Mouse . PubMed: 22719835
    • Hirono S  et al. Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci : (2009). IHC-FoFr ; Human . PubMed: 19817750

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Granzyme A antibody [GA6]

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 24°C
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: citrate buffer
    Sample
    Human Tissue sections (heart)
    Specification
    heart
    Permeabilization
    No
    Fixative
    formalin
    Read More

    Abcam user community

    Verified customer

    Submitted Oct 29 2014

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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