Anti-Granzyme A antibody [GA6] (ab10870)

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Key features and details

  • Mouse monoclonal [GA6] to Granzyme A
  • Reacts with: Human
  • Isotype: IgG1

Overview

  • Product name

    Anti-Granzyme A antibody [GA6]
    See all Granzyme A primary antibodies

  • Description

    Mouse monoclonal [GA6] to Granzyme A

  • Host species

    Mouse

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant Granzyme A (Human).

Properties

Target

  • Function

    This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.

  • Sequence similarities

    Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.

  • Cellular localization

    Secreted. Cytoplasmic granule.
  • Information by UniProt

  • Database links

    • Alternative names

      • CTL tryptase antibody
      • CTLA3 antibody
      • Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody
      • Cytotoxic T lymphocyte associated serine esterase 3 antibody
      • Cytotoxic T lymphocyte proteinase 1 antibody
      • Cytotoxic T-lymphocyte proteinase 1 antibody
      • Fragmentin 1 antibody
      • Fragmentin-1 antibody
      • GRAA_HUMAN antibody
      • Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3 antibody
      • Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease) antibody
      • Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3) antibody
      • Granzyme A antibody
      • Granzyme A precursor antibody
      • Granzyme-1 antibody
      • GZMA antibody
      • H factor antibody
      • Hanukah factor serine protease antibody
      • Hanukkah factor antibody
      • HF antibody
      • HFSP antibody
      • TSP1 antibody
      see all

    References (3)

    Publishing research using ab10870? Please let us know so that we can cite the reference in this datasheet.

    ab10870 has been referenced in 3 publications.

    • Papalampros A  et al. Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPa Expression. Cancers (Basel) 12:N/A (2020). PubMed: 32645996
    • Li H  et al. Glucocorticoid Receptor and Sequential P53 Activation by Dexamethasone Mediates Apoptosis and Cell Cycle Arrest of Osteoblastic MC3T3-E1 Cells. PLoS One 7:e37030 (2012). WB ; Mouse . PubMed: 22719835
    • Hirono S  et al. Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci : (2009). IHC-FoFr ; Human . PubMed: 19817750

    Customer reviews and Q&As

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    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Granzyme A antibody [GA6]

     Good
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Blocking step
    Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 24°C
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: citrate buffer
    Sample
    Human Tissue sections (heart)
    Specification
    heart
    Permeabilization
    No
    Fixative
    formalin
    Read More

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    Verified customer

    Submitted Oct 29 2014

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