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  1. Link

    granzyme-m-antibody-ab201102.pdf

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Cell Biology Apoptosis Extracellular Signals Granzymes
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Anti-Granzyme M antibody (ab201102)

  • Datasheet
  • SDS
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  • Western blot - Anti-Granzyme M antibody (ab201102)

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Primary

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Protein

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  • Datasheet
  • References
  • Protocols

Overview

  • Product name

    Anti-Granzyme M antibody
    See all Granzyme M primary antibodies
  • Description

    Rabbit polyclonal to Granzyme M
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Granzyme M.
    Database link: P51124

  • Positive control

    • HeLa, PC12 and sp20 whole cell lysates.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab201102 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Extracellular Signals
    • Granzymes
    • Cell Biology
    • Proteolysis / Ubiquitin
    • Proteolytic enzymes
    • Other proteases

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
  • Recombinant Protein

    • Recombinant Human Granzyme M protein (ab158624)
  • Related Products

    • Recombinant Human Granzyme M protein (ab158624)

Applications

Our Abpromise guarantee covers the use of ab201102 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 28 kDa.

Target

  • Function

    Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
  • Tissue specificity

    Highly and constitutively expressed in activated natural killer (NK) cells.
  • Sequence similarities

    Belongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localization

    Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
  • Target information above from: UniProt accession P51124 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3004 Human
    • Entrez Gene: 16904 Mouse
    • Entrez Gene: 29252 Rat
    • Omim: 600311 Human
    • SwissProt: P51124 Human
    • SwissProt: Q03238 Rat
    • Unigene: 465511 Human
    • Unigene: 9838 Rat
    • Alternative names

      • GRAM_HUMAN antibody
      • Granzyme M (lymphocyte met ase 1) antibody
      • Granzyme M antibody
      • GranzymeM antibody
      • GZM M antibody
      • Gzmm antibody
      • HU Met 1 antibody
      • HU-Met-1 antibody
      • LMET 1 antibody
      • LMET1 antibody
      • Lymphocyte met ase 1 antibody
      • MET 1 antibody
      • Met 1 serine protease antibody
      • Met ase antibody
      • Met-1 serine protease antibody
      • Met-ase antibody
      • MET1 antibody
      • Met1 serine protease antibody
      • Natural killer cell granular protease antibody
      see all

    Images

    • Western blot - Anti-Granzyme M antibody (ab201102)
      Western blot - Anti-Granzyme M antibody (ab201102)
      All lanes : Anti-Granzyme M antibody (ab201102)

      Lane 1 : HeLa whole cell lysate
      Lane 2 : PC12 whole cell lysate
      Lane 3 : sp20 whole cell lysate

      Predicted band size: 28 kDa

    Protocols

    • Western blot protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References

    ab201102 has not yet been referenced specifically in any publications.

    Publishing research using ab201102? Please let us know so that we can cite the reference in this datasheet.

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