Anti-GRIM19 antibody [EPR4471(2)] (ab109017)


  • Product name
    Anti-GRIM19 antibody [EPR4471(2)]
    See all GRIM19 primary antibodies
  • Description
    Rabbit monoclonal [EPR4471(2)] to GRIM19
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, ICCmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human GRIM19 aa 50-150 (internal sequence). The exact sequence is proprietary.

  • Positive control
    • HeLa, Ramos, Jurkat, and 293T cell lysates; Human kidney tissue
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.


Associated products


Our Abpromise guarantee covers the use of ab109017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 17 kDa.
IHC-P 1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC 1/50 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt or IP.
  • Target

    • Function
      Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
    • Tissue specificity
      Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
    • Involvement in disease
      Defects in NDUFA13 may be a cause of susceptibility to Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]. Hurthle cell thyroid carcinoma accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms.
    • Sequence similarities
      Belongs to the complex I NDUFA13 subunit family.
    • Developmental stage
      Expressed in numerous fetal tissues.
    • Cellular localization
      Mitochondrion inner membrane. Nucleus. May be translocated into the nucleus upon IFN/RA treatment.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2700054G14Rik antibody
      • AU022060 antibody
      • B16.6 antibody
      • CDA016 antibody
      • Cell death regulatory protein antibody
      • Cell death regulatory protein GRIM-19 antibody
      • CGI-39 antibody
      • CGI39 protein antibody
      • CI-B16.6 antibody
      • Complex I-B16.6 antibody
      • FLJ58045 antibody
      • FLJ59191 antibody
      • Gene associated with retinoic and IFN-induced mortality 19 protein antibody
      • Gene associated with retinoic and interferon-induced mortality 19 protein antibody
      • Gene associated with retinoic interferon induced mortality 19 protein antibody
      • GRIM-19 antibody
      • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 antibody
      • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 antibody
      • NADH ubiquinone oxidoreductase B16.6 subunit antibody
      • NADH-ubiquinone oxidoreductase B16.6 subunit antibody
      • NDUAD_HUMAN antibody
      • NDUFA13 antibody
      • RGD1565358 antibody
      see all


    • All lanes : Anti-GRIM19 antibody [EPR4471(2)] (ab109017) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : Ramos cell lysate
      Lane 3 : Jurkat cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 17 kDa

    • Immunohistochemical analysis of GRIM19 in paraffin-embedded Human kidney tissue using ab109017 at 1/100 dilution.


    ab109017 has not yet been referenced specifically in any publications.

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