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Signal Transduction Protein Phosphorylation Ser / Thr Kinases GPCR Kinases
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Anti-GRK3 antibody - N-terminal (ab137764)

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Western blot - Anti-GRK3 antibody - N-terminal (ab137764)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRK3 antibody - N-terminal (ab137764)

Key features and details

  • Rabbit polyclonal to GRK3 - N-terminal
  • Suitable for: IHC-P, WB
  • Reacts with: Human
  • Isotype: IgG

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Protein
Product image
Recombinant human GRK3 protein (ab131701)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-GRK3 antibody - N-terminal
    See all GRK3 primary antibodies
  • Description

    Rabbit polyclonal to GRK3 - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-225 of Human GRK3 (Uniprot ID: P35626).

  • Positive control

    • HeLa whole cell lysate, Human H1299 xenograft tissue, and MOLT4 cell line.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • GPCR Kinases
    • Signal Transduction
    • Signaling Pathway
    • G Protein Signaling
    • GPCR

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab150035)
    • HeLa whole cell lysate (ab29545)
    • MOLT-4 whole cell lysate (ab7912)
  • Recombinant Protein

    • Recombinant human GRK3 protein (ab131701)
  • Related Products

    • Recombinant human GRK3 protein (ab131701)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab137764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
WB
1/500 - 1/3000. Predicted molecular weight: 80 kDa.
Notes
IHC-P
1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
WB
1/500 - 1/3000. Predicted molecular weight: 80 kDa.

Target

  • Function

    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • Sequence similarities

    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • Target information above from: UniProt accession P35626 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 282136 Cow
    • Entrez Gene: 157 Human
    • Entrez Gene: 320129 Mouse
    • Entrez Gene: 25372 Rat
    • Omim: 109636 Human
    • SwissProt: P26818 Cow
    • SwissProt: P35626 Human
    • SwissProt: Q3UYH7 Mouse
    • SwissProt: P26819 Rat
    • Unigene: 657494 Human
    • Unigene: 285619 Mouse
    • Unigene: 9861 Rat
    see all
  • Alternative names

    • ADRBK2 antibody
    • Adrenergic, beta, receptor kinase 2 antibody
    • ARBK2_HUMAN antibody
    • BARK2 antibody
    • Beta adrenergic receptor kinase 2 antibody
    • Beta ARK 2 antibody
    • Beta-adrenergic receptor kinase 2 antibody
    • Beta-ARK-2 antibody
    • EC 2.7.11.15 antibody
    • G protein coupled receptor kinase 3 antibody
    • G-protein-coupled receptor kinase 3 antibody
    • GRK3 antibody
    see all

Images

  • Western blot - Anti-GRK3 antibody - N-terminal (ab137764)
    Western blot - Anti-GRK3 antibody - N-terminal (ab137764)
    Anti-GRK3 antibody - N-terminal (ab137764) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size: 80 kDa



    7.5% SDS PAGE
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRK3 antibody - N-terminal (ab137764)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRK3 antibody - N-terminal (ab137764)
    Immunohistochemical analysis of paraffin-embedded Human HT1299 xenograft tissue, labelling GRK3 with ab137764 at 1/100 dilution.

Protocols

  • Western blot protocols
  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab137764? Please let us know so that we can cite the reference in this datasheet.

ab137764 has not yet been referenced specifically in any publications.

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