Anti-Growth Hormone antibody (ab126882)
Rabbit polyclonal Growth Hormone antibody. Validated in WB, IP, ELISA, IHC and tested in Rat. Independently reviewed in 2 review(s). Immunogen corresponding to recombinant full length protein.
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Overview
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Product name
Anti-Growth Hormone antibody
See all Growth Hormone primary antibodies -
Description
Rabbit polyclonal to Growth Hormone -
Host species
Rabbit -
Tested applications
Suitable for: WB, IP, ELISA, IHC-Pmore details -
Species reactivity
Reacts with: Rat -
Immunogen
Recombinant full length mature protein, corresponding to amino acids 27-216 of Rat Growth Hormone, derived from E.coli.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab126882 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | Use at an assay dependent concentration. Predicted molecular weight: 25 kDa. 0.5µg (0.5ng/lane) | |
IP | Use at an assay dependent concentration. | |
ELISA | Use at an assay dependent concentration. Use 0.2ng/well | |
IHC-P | Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. -
Involvement in disease
Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. -
Sequence similarities
Belongs to the somatotropin/prolactin family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 24391 Rat
- SwissProt: P01244 Rat
- Unigene: 146351 Rat
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Alternative names
- gH antibody
- GH-N antibody
- GH1 antibody
see all
References
ab126882 has not yet been referenced specifically in any publications.