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Signal Transduction Growth Factors/Hormones Hormones
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RecombinantRabMAb

Recombinant Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Western blot - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
  • Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR11048(B)] to Growth Hormone
  • Suitable for: WB, IHC-P
  • Reacts with: Human

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Overview

  • Product name

    Anti-Growth Hormone antibody [EPR11048(B)]
    See all Growth Hormone primary antibodies
  • Description

    Rabbit monoclonal [EPR11048(B)] to Growth Hormone
  • Host species

    Rabbit
  • Specificity

    ab157456 is predicted to cross-react with GH2.
  • Tested applications

    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human Growth Hormone (Uniprot: P01241).

  • Positive control

    • Human placenta cell lysate; Human pituitary gland and placenta tissues.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR11048(B)
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Growth Factors/Hormones
    • Hormones
    • Developmental Biology
    • Post embryonic development
    • Growth hormones

Associated products

  • Alternative Versions

    • Anti-Growth Hormone antibody [EPR11048(B)] - BSA and Azide free (ab249326)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Recombinant Protein

    • Recombinant human Growth Hormone protein (ab110680)

Applications

Our Abpromise guarantee covers the use of ab157456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 25 kDa.
IHC-P 1/250 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt.
  • Target

    • Function

      Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
    • Involvement in disease

      Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
      Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
      Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
      Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
    • Sequence similarities

      Belongs to the somatotropin/prolactin family.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession P01241 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 2688 Human
      • Omim: 139250 Human
      • SwissProt: P01241 Human
      • Unigene: 655229 Human
      • Alternative names

        • gH antibody
        • GH-N antibody
        • GH1 antibody
        • GHB5 antibody
        • GHN antibody
        • Growth hormone 1 antibody
        • Growth hormone antibody
        • Growth hormone B5 antibody
        • Growth hormone, normal antibody
        • Growth hormone, pituitary antibody
        • HG1 antibody
        • hGH-N antibody
        • IGHD1B antibody
        • Pituitary growth hormone antibody
        • RNGHGP antibody
        • SOMA_HUMAN antibody
        • Somatotropin antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

        ab157456 showing -ve staining in Human normal tonsil.

        Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

        ab157456 showing -ve staining in Human normal pancreas.

        Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

        ab157456 showing -ve staining in Human normal kidney.

        Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

      • Western blot - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Western blot - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Anti-Growth Hormone antibody [EPR11048(B)] (ab157456) at 1/1000 dilution + Human placenta cell lysate at 10 µg

        Secondary
        Goat anti-rabbit HRP at 1/2000 dilution

        Predicted band size: 25 kDa

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

        Immunohistochemical analysis of Paraffin-embedded Human pituitary gland tissue labeling Human Growth Hormone with ab157456 at 1/250 dilution.

        Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

        Immunohistochemical analysis of Paraffin-embedded Human placenta tissue labeling Human Growth Hormone with ab157456 at 1/250 dilution

        Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

      • Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)
        Anti-Growth Hormone antibody [EPR11048(B)] (ab157456)

      Protocols

      • Western blot protocols
      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab157456? Please let us know so that we can cite the reference in this datasheet.

      ab157456 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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