Anti-GRP78 BiP antibody (ab21685)

Rabbit polyclonal GRP78 BiP antibody. Validated in WB, IP, IHC, EM, ICC/IF and tested in Mouse, Rat, Dog, Human, Pig, African green monkey, Chinese hamster. Cited in 206 publication(s).

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ab21685 has been referenced in 211 publications.

  • Banerjee S  et al. Sulphur dioxide ameliorates colitis related pathophysiology and inflammation. Toxicology 412:63-78 (2019). PubMed: 30503585
  • Ning B  et al. Endoplasmic reticulum stress induced autophagy in 6-OHDA-induced Parkinsonian rats. Brain Res Bull 146:224-227 (2019). PubMed: 30625371
  • Cassimeris L  et al. Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis. BMC Vet Res 15:24 (2019). PubMed: 30630474
  • Araujo TLS  et al. Cell-surface HSP70 associates with thrombomodulin in endothelial cells. Cell Stress Chaperones 24:273-282 (2019). PubMed: 30645756
  • Witte ME  et al. Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron 101:615-624.e5 (2019). PubMed: 30686733
  • Yu M  et al. Lutein and Zeaxanthin Isomers Reduce Photoreceptor Degeneration in the Pde6brd10 Mouse Model of Retinitis Pigmentosa. Biomed Res Int 2018:4374087 (2018). PubMed: 30643804
  • Huang Q  et al. DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways. Front Pharmacol 9:1423 (2018). PubMed: 30564125
  • Xie ZY  et al. Acid-Sensing Ion Channel 1a Regulates Fate of Rat Nucleus Pulposus Cells in Acid Stimulus Through Endoplasmic Reticulum Stress. Biores Open Access 7:2-9 (2018). PubMed: 29445584
  • Stabell AC  et al. Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir. Elife 7:N/A (2018). PubMed: 29557779
  • Dauer P  et al. GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells. Mol Oncol 12:1498-1512 (2018). PubMed: 29738634
  • Sun X  et al. Neuritin Attenuates Neuronal Apoptosis Mediated by Endoplasmic Reticulum Stress In Vitro. Neurochem Res 43:1383-1391 (2018). PubMed: 29790068
  • Hong J  et al. Involvement of miR-455 in the protective effect of H2S against chemical hypoxia-induced injury in BEAS-2B cells. Pathol Res Pract 214:1804-1810 (2018). PubMed: 30193773
  • Lu Y  et al. Protective effects of Danzhi jiangtang capsule on vascular endothelial damages induced by high-fat diet and palmitic acid. Biomed Pharmacother 107:1631-1640 (2018). PubMed: 30257381
  • Ho DH  et al. LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase. Cell Biochem Funct 36:431-442 (2018). PubMed: 30411383
  • Jung J  et al. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep 8:16659 (2018). PubMed: 30413759
  • Chen L  et al. Nuclear factor-kappa B-dependent X-box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation. Cell Prolif N/A:e12542 (2018). PubMed: 30430692
  • Solis GM  et al. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms. Elife 7:N/A (2018). PubMed: 30479271
  • Ruebsam A  et al. A specific phosphorylation regulates the protective role of aA-crystallin in diabetes. JCI Insight 3:N/A (2018). PubMed: 29467334
  • Wang L  et al. TIPE-2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3-kinase/AKT signaling pathway. Mol Med Rep 17:7017-7026 (2018). PubMed: 29568863
  • Liu X  et al. Protective effect of curcumin against ultraviolet A irradiation-induced photoaging in human dermal fibroblasts. Mol Med Rep 17:7227-7237 (2018). PubMed: 29568864
  • Zhao D  et al. Identification of Glucose-Regulated Protein 78 (GRP78) as a Receptor in BHK-21 Cells for Duck Tembusu Virus Infection. Front Microbiol 9:694 (2018). PubMed: 29692766
  • Wang B  et al. The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson's Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy. Front Mol Neurosci 11:120 (2018). PubMed: 29731707
  • Zhang L  et al. Vitamin D attenuates pressure overload-induced cardiac remodeling and dysfunction in mice. J Steroid Biochem Mol Biol 178:293-302 (2018). PubMed: 29337094
  • Kang T  et al. Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality. Biomaterials 164:80-97 (2018). PubMed: 29499438
  • Mathias S  et al. Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy. J Biotechnol 271:47-55 (2018). ICC . PubMed: 29477386
  • Ruggiero C  et al. The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways. Mol Cell Endocrinol N/A:N/A (2018). WB . PubMed: 29474877
  • Zhang L  et al. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) attenuates silicotic fibrosis by suppressing apoptosis of alveolar type II epithelial cells via mediation of endoplasmic reticulum stress. Toxicol Appl Pharmacol 350:1-10 (2018). WB ; Rat . PubMed: 29684394
  • George AK  et al. Exercise Mitigates Alcohol Induced Endoplasmic Reticulum Stress Mediated Cognitive Impairment through ATF6-Herp Signaling. Sci Rep 8:5158 (2018). PubMed: 29581524
  • Cui F  et al. Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats. Life Sci 205:145-154 (2018). PubMed: 29733850
  • Lei X  et al. Diazoxide inhibits of ER stress-mediated apoptosis during oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Mol Med Rep 17:8039-8046 (2018). PubMed: 29693708
  • Yuan X  et al. Allergy immunotherapy restores airway epithelial barrier dysfunction through suppressing IL-25 -induced endoplasmic reticulum stress in asthma. Sci Rep 8:7950 (2018). PubMed: 29784924
  • Xi J  et al. Suppression of GRP78 sensitizes human colorectal cancer cells to oxaliplatin by downregulation of CD24. Oncol Lett 15:9861-9867 (2018). PubMed: 29805687
  • Fu Z  et al. Estrogen receptor-a36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells. Oncol Lett 15:10031-10036 (2018). PubMed: 29805694
  • Cheng X  et al. Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer. Cancer Lett 431:105-114 (2018). WB ; Human . PubMed: 29859300
  • Zhang L  et al. Particle-induced SIRT1 downregulation promotes osteoclastogenesis and osteolysis through ER stress regulation. Biomed Pharmacother 104:300-306 (2018). WB ; Mouse . PubMed: 29775898
  • Luo T  et al. ERK1/2 MAPK promotes autophagy to suppress ER stress-mediated apoptosis induced by cadmium in rat proximal tubular cells. Toxicol In Vitro 52:60-69 (2018). Rat . PubMed: 29870746
  • Wiersma M  et al. Torpor-arousal cycles in Syrian hamster heart are associated with transient activation of the protein quality control system. Comp Biochem Physiol B Biochem Mol Biol 223:23-28 (2018). WB . PubMed: 29894736
  • Stacchiotti A  et al. Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulating Endoplasmic Reticulum Stress and Mitochondrial-Related Apoptosis in Rat Kidney. Nutrients 10:N/A (2018). PubMed: 29843457
  • Shu Q  et al. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-?B activation in reactive astrocytes. J Cell Biochem 119:6584-6597 (2018). PubMed: 29665049
  • Martinotti S  et al. (-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress. J Cell Physiol 233:7082-7090 (2018). PubMed: 29744892
  • Yang F  et al. IRE1a aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. Free Radic Biol Med 124:395-407 (2018). PubMed: 29969718
  • Lin H  et al. Knockdown of Herp alleviates hyperhomocysteinemia mediated atherosclerosis through the inhibition of vascular smooth muscle cell phenotype switching. Int J Cardiol 269:242-249 (2018). PubMed: 30017525
  • Kwon D  et al. Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma. Lung Cancer 122:131-137 (2018). PubMed: 30032821
  • Xu W  et al. Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-mediated Apoptosis and Blood-Brain Barrier Disruption: Possible Involvement of ATF6/CHOP Pathway. Neuroscience 388:284-296 (2018). PubMed: 30036660
  • Zheng WL  et al. ROS-Mediated Cell Cycle Arrest and Apoptosis Induced by Zearalenone in Mouse Sertoli Cells via ER Stress and the ATP/AMPK Pathway. Toxins (Basel) 10:N/A (2018). PubMed: 29301253
  • Leipnitz G  et al. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Sci Rep 8:1165 (2018). WB ; Human . PubMed: 29348607
  • Zheng W  et al. Zearalenone altered the cytoskeletal structure via ER stress- autophagy- oxidative stress pathway in mouse TM4 Sertoli cells. Sci Rep 8:3320 (2018). PubMed: 29463855
  • Moriya C  et al. PRDM14 directly interacts with heat shock proteins HSP90a and glucose-regulated protein 78. Cancer Sci 109:373-383 (2018). IP . PubMed: 29178343
  • Zhu P  et al. Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway. Redox Biol 16:157-168 (2018). WB . PubMed: 29502045
  • Shen W  et al. Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. Nucleic Acids Res 46:2204-2217 (2018). PubMed: 29390093
  • Liu D  et al. Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance. Front Mol Neurosci 11:72 (2018). PubMed: 29559889
  • Li PC  et al. Seawater inhalation induces acute lung injury via ROS generation and the endoplasmic reticulum stress pathway. Int J Mol Med 41:2505-2516 (2018). PubMed: 29436612
  • Wang L  et al. Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme. Cell Death Dis 8:e2807 (2017). WB ; Human . PubMed: 28518150
  • Nakazawa H  et al. Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1a and mTORC1: Role of protein farnesylation. Sci Rep 7:6618 (2017). PubMed: 28747716
  • Yao Y  et al. A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure. Nat Commun 8:133 (2017). PubMed: 28743963
  • Guo H  et al. Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKa-regulated autophagy induction in streptozotocin-induced diabetic nephropathy. Sci Rep 7:6852 (2017). PubMed: 28761152
  • Putranto EW  et al. Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene. Oncol Lett 14:1041-1048 (2017). PubMed: 28693271
  • Gai Z  et al. Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage. Sci Rep 7:9815 (2017). PubMed: 28852062
  • Gan L  et al. Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue. Front Immunol 8:1507 (2017). PubMed: 29250056
  • Kasetti RB  et al. Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork. Sci Rep 7:14951 (2017). PubMed: 29097767
  • Hu Y  et al. Inhibition of endoplasmic reticulum stress is involved in the neuroprotective effect of aFGF in neonatal hypoxic-ischaemic brain injury. Oncotarget 8:60941-60953 (2017). PubMed: 28977836
  • Nakamura O  et al. Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress. Clin Ophthalmol 11:1825-1834 (2017). PubMed: 29066860
  • Nain M  et al. GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells. J Virol 91:N/A (2017). PubMed: 28053106
  • Guiraud S  et al. HANAC Col4a1 Mutation in Mice Leads to Skeletal Muscle Alterations due to a Primary Vascular Defect. Am J Pathol 187:505-516 (2017). PubMed: 28056338
  • Tschurtschenthaler M  et al. Defective ATG16L1-mediated removal of IRE1a drives Crohn's disease-like ileitis. J Exp Med 214:401-422 (2017). PubMed: 28082357
  • Bowen AB  et al. Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines. Elife 6:N/A (2017). PubMed: 28875935
  • Lin  et al. Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites. J Pharmacol Exp Ther 363:12-19 (2017). PubMed: 28882992
  • Li Y  et al. Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells. Int J Mol Med 40:1405-1414 (2017). PubMed: 28949381
  • Qie X  et al. Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage. Front Pharmacol 8:639 (2017). PubMed: 28959203
  • Lee S  et al. Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease. Oncotarget 8:63370-63381 (2017). PubMed: 28968997
  • Alm PS  et al. Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle. Mol Metab 6:621-630 (2017). PubMed: 28702319
  • Wang X  et al. Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma. EBioMedicine 15:137-149 (2017). WB, IHC-P ; Mouse, Human . PubMed: 28024734
  • Li J  et al. Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Stem Cell Res Ther 8:107 (2017). WB ; Rat . PubMed: 28482861
  • Aksoy P & Meneses PI The Role of DCT in HPV16 Infection of HaCaTs. PLoS One 12:e0170158 (2017). ICC/IF . PubMed: 28095444
  • Lovric S  et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest 127:912-928 (2017). WB ; Mouse . PubMed: 28165339
  • Wang Y  et al. The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein. PLoS One 12:e0180731 (2017). ICC/IF ; Hamster . PubMed: 28686733
  • Piret SE  et al. A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. Dis Model Mech 10:773-786 (2017). IHC-P ; Mouse . PubMed: 28325753
  • Zhang Z  et al. Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Oxid Med Cell Longev 2017:5736506 (2017). WB ; Human . PubMed: 28630659
  • Hammad AS  et al. Structure-activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro. Cell Stress Chaperones 22:417-428 (2017). PubMed: 28397086
  • López I  et al. p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress. Cell Death Differ 24:1717-1729 (2017). WB, IP, ICC/IF . PubMed: 28622297
  • Hu HJ  et al. Protective effects of hydrogen sulfide against angiotensin II-induced endoplasmic reticulum stress in HUVECs. Mol Med Rep 15:2213-2222 (2017). PubMed: 28259956
  • Hasegawa H  et al. Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2a phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic. MAbs 9:854-873 (2017). PubMed: 28379093
  • Stewart SE  et al. A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface. J Cell Sci 130:3234-3247 (2017). PubMed: 28775154
  • Qin EY  et al. Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Cell 170:845-859.e19 (2017). PubMed: 28823557
  • Fan J  et al. cTAGE5 deletion in pancreatic ß cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol 216:4153-4164 (2017). PubMed: 29133483
  • Fessart D  et al. Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties. Elife 5:N/A (2016). PubMed: 27240165
  • Andreu-Fernández V  et al. The C-terminal Domains of Apoptotic BH3-only Proteins Mediate Their Insertion into Distinct Biological Membranes. J Biol Chem 291:25207-25216 (2016). PubMed: 27758854
  • Wei SG  et al. Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats. Hypertension 67:229-36 (2016). PubMed: 26573710
  • Long Z  et al. The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. Oncotarget 7:42059-42070 (2016). PubMed: 27275542
  • Pang XX  et al. Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice. Kidney Blood Press Res 41:434-49 (2016). PubMed: 27467277
  • Ponnalagu D  et al. Data supporting characterization of CLIC1, CLIC4, CLIC5 and DmCLIC antibodies and localization of CLICs in endoplasmic reticulum of cardiomyocytes. Data Brief 7:1038-44 (2016). PubMed: 27104215
  • López-González I  et al. Limited Unfolded Protein Response and Inflammation in Neuroserpinopathy. J Neuropathol Exp Neurol 75:121-33 (2016). PubMed: 26733586
  • Law C  et al. Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1. J Neurosci 36:561-76 (2016). PubMed: 26758845
  • Nakadate K  et al. Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity. Biomed Res Int 2016:5251738 (2016). PubMed: 27437400
  • Dafinca R  et al. C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Stem Cells 34:2063-78 (2016). PubMed: 27097283
  • Sun XY  et al. Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-induced apoptosis. Mol Med Rep 13:661-8 (2016). WB, IHC-P ; Rat . PubMed: 26647757
  • Rodríguez-Martínez E  et al. The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus. Front Aging Neurosci 8:245 (2016). WB ; Rat . PubMed: 27826237
  • Berthoud VM  et al. The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses. J Biol Chem 291:17569-78 (2016). WB ; Mouse . PubMed: 27317663
  • Gai Z  et al. Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice. J Biol Chem 291:2397-411 (2016). PubMed: 26655953
  • Kang K  et al. Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa. Sci Rep 6:22632 (2016). IHC, WB . PubMed: 26961159
  • Wei SG  et al. Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. Am J Physiol Heart Circ Physiol 311:H871-H880 (2016). PubMed: 27496879
  • Wang C  et al. Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress. Sci Rep 6:34330 (2016). WB ; Human . PubMed: 27680712
  • Oetjen S  et al. Revisiting the neuronal localization and trafficking of CLN3 in juvenile neuronal ceroid lipofuscinosis. J Neurochem 139:456-470 (2016). PubMed: 27453211
  • Magarin M  et al. Embryonic cardiomyocytes can orchestrate various cell protective mechanisms to survive mitochondrial stress. J Mol Cell Cardiol 97:1-14 (2016). PubMed: 27106802
  • Sclip A  et al. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS One 11:e0158295 (2016). WB . PubMed: 27348751
  • Davis MA  et al. Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. Drug Des Devel Ther 10:1837-46 (2016). PubMed: 27330277
  • Lyu L  et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB J 30:1087-95 (2016). PubMed: 26590164
  • Ohta Y  et al. Sex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosis. Hum Mol Genet 25:4771-4786 (2016). PubMed: 28175304
  • Lalani SR  et al. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. Am J Hum Genet 98:347-57 (2016). PubMed: 26805781
  • Sanchez-Martinez A  et al. Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models. Sci Rep 6:31380 (2016). WB . PubMed: 27539639
  • Nie T  et al. Regulation of ER stress-induced autophagy by GSK3ß-TIP60-ULK1 pathway. Cell Death Dis 7:e2563 (2016). PubMed: 28032867
  • Marek I  et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS One 11:e0150471 (2016). WB . PubMed: 26938996
  • Seref-Ferlengez Z  et al. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One 11:e0155107 (2016). PubMed: 27159053
  • Heindryckx F  et al. Endoplasmic reticulum stress enhances fibrosis through IRE1a-mediated degradation of miR-150 and XBP-1 splicing. EMBO Mol Med 8:729-44 (2016). PubMed: 27226027
  • Hasan M  et al. Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity 43:463-74 (2015). PubMed: 26320659
  • MacLeod AK  et al. Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models. Cancer Res 75:4573-81 (2015). PubMed: 26363009
  • Nayak RC  et al. Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells. J Clin Invest 125:3103-16 (2015). WB . PubMed: 26193632
  • Cai X  et al. Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res 140:130-138 (2015). PubMed: 26325328
  • Ciplys E  et al. High-level secretion of native recombinant human calreticulin in yeast. Microb Cell Fact 14:165 (2015). WB . PubMed: 26471510
  • Wang Y  et al. PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death. Oncotarget 6:25252-65 (2015). PubMed: 26259235
  • Katoh H  et al. Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin-proteasome pathway. J Virol 89:3188-99 (2015). PubMed: 25552722
  • DiGiuseppe S  et al. Topography of the Human Papillomavirus Minor Capsid Protein L2 during Vesicular Trafficking of Infectious Entry. J Virol 89:10442-52 (2015). PubMed: 26246568
  • Rogers SW & Gahring LC Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS One 10:e0143319 (2015). PubMed: 26619345
  • Friebe S  et al. Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8. PLoS One 10:e0119864 (2015). PubMed: 25781883
  • Guo XF & Yang XJ Endoplasmic reticulum stress response in spontaneously hypertensive rats is affected by myocardial ischemia reperfusion injury. Exp Ther Med 9:319-326 (2015). PubMed: 25574192
  • Sheehy RM  et al. Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biol Ther 16:1259-68 (2015). PubMed: 26046259
  • Yeganeh B  et al. Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response. World J Gastroenterol 21:13225-39 (2015). PubMed: 26715805
  • Oishi N  et al. XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death Dis 6:e1763 (2015). WB . PubMed: 25973683
  • Ostapchenko VG  et al. The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to ß-Amyloid Oligomer-Related Neurotoxicity and Memory Impairment. J Neurosci 35:15157-69 (2015). PubMed: 26558786
  • Zhang E  et al. Endoplasmic reticulum stress impairment in the spinal dorsal horn of a neuropathic pain model. Sci Rep 5:11555 (2015). PubMed: 26109318
  • Tewari R  et al. Induced oligomerization targets Golgi proteins for degradation in lysosomes. Mol Biol Cell 26:4427-37 (2015). WB ; Human . PubMed: 26446839
  • Veerbeek JH  et al. Endoplasmic reticulum stress is induced in the human placenta during labour. Placenta 36:88-92 (2015). IHC ; Human . PubMed: 25434970
  • Datta P  et al. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proc Natl Acad Sci U S A 112:E4400-9 (2015). IF ; Mouse . PubMed: 26216965
  • Van Kampen JM  et al. The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease. PLoS One 10:e0139694 (2015). PubMed: 26439489
  • Masson GS  et al. Toll-like receptor 4 promotes autonomic dysfunction, inflammation and microglia activation in the hypothalamic paraventricular nucleus: role of endoplasmic reticulum stress. PLoS One 10:e0122850 (2015). WB, IF ; Rat . PubMed: 25811788
  • Cheng D  et al. Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells. J Lipid Res 56:1583-93 (2015). PubMed: 26089538
  • Feng X  et al. Behavioral stress reduces RIP140 expression in astrocyte and increases brain lipid accumulation. Brain Behav Immun 46:270-9 (2015). IHC ; Mouse . PubMed: 25697398
  • Ben-Gedalya T  et al. Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction. EMBO J 34:2820-39 (2015). PubMed: 26438723
  • Ono M  et al. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1. Mol Ther 23:549-60 (2015). PubMed: 25373521
  • Sun X  et al. Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med 19:581-94 (2015). WB ; Rat . PubMed: 25418486
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