Key features and details
- Mouse polyclonal to GRX2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-GRX2 antibody
See all GRX2 primary antibodies
DescriptionMouse polyclonal to GRX2
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Human
- Lysate from 293T cells transfected with GRX2; HeLa cells.
This product was previously labelled as Glutaredoxin 2
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.4
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab167207 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 14 kDa.|
|ICC/IF||Use a concentration of 10 µg/ml.|
FunctionGlutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Tissue specificityWidely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
Sequence similaritiesBelongs to the glutaredoxin family.
Contains 1 glutaredoxin domain.
Cellular localizationMitochondrion and Nucleus.
- Information by UniProt
- bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody
- bA101E13.1 antibody
- CGI133 antibody
All lanes : Anti-GRX2 antibody (ab167207) at 1 µg/ml
Lane 1 : Lysate from 293T cells transfected with GRX2
Lane 2 : 293T cell lysate Non-transfected
Lysates/proteins at 15 µg per lane.
Predicted band size: 14 kDa
Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, labeling GRX2 using ab167207 at 10 µg/ml.
ab167207 has not yet been referenced specifically in any publications.