Overview

  • Product name
  • Description
    Rabbit polyclonal to GRXCR1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human GRXCR1 aa 90-120 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: A8MXD5

  • Positive control
    • Mouse kidney tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab170707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 32 kDa.

Target

  • Function
    May play a role in actin filament architecture in developing stereocilia of sensory cells.
  • Tissue specificity
    Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.
  • Involvement in disease
    Defects in GRXCR1 are the cause of deafness autosomal recessive type 25 (DFNB25) [MIM:613285]. DFNB25 is characterized by moderate to severe or profound hearing loss which is progressive in some individuals but not in others. Speech development is impaired in some but not all affected individuals and vestibular dysfunction is observed in some affected individuals.
  • Sequence similarities
    Belongs to the GRXCR1 family.
    Contains 1 glutaredoxin domain.
  • Cellular localization
    Cell projection > stereocilium. Cell projection > microvillus. Cell projection > kinocilium. In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia.
  • Information by UniProt
  • Database links
  • Alternative names
    • DFNB25 antibody
    • Glutaredoxin domain-containing cysteine-rich protein 1 antibody
    • Glutaredoxin, cysteine rich 1 antibody
    • GRCR1_HUMAN antibody
    • Grxcr1 antibody
    see all

Images

  • Anti-GRXCR1 antibody (ab170707) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 32 kDa

References

ab170707 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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