Overview

  • Product name

    GS 39783, GABAB positive allosteric modulator
  • Description

    Novel, GABAB positive allosteric modulator
  • Biological description

    Novel, GABAB positive allosteric modulator (EC50 = 3 μM for [35S]GTPγS binding). Shows anxiolytic and antiaddictive effects in vivo. Blood-brain barrier permeable. Orally active.
  • Purity

    > 99%
  • CAS Number

    39069-52-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N4,N6-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine
  • Molecular weight

    337.44
  • Molecular formula

    C15H23N5O2S
  • PubChem identifier

    6604928
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CSC1=NC(=C(C(=N1)NC2CCCC2)[N+](=O)[O-])NC3CCCC3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mombereau C  et al. GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation. J Pharmacol Exp Ther 321:172-7 (2007). Read more (PubMed: 17215447) »
  • Cryan JF  et al. Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. J Pharmacol Exp Ther 310:952-63 (2004). Read more (PubMed: 15113848) »
  • Urwyler S  et al. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function. J Pharmacol Exp Ther 307:322-30 (2003). Read more (PubMed: 12954816) »

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