GSK-1016790A, TRPV4 channel agonist (ab146191)
Key features and details
- Novel, potent TRPV4 channel agonist
- CAS Number: 942206-85-1
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK-1016790A, TRPV4 channel agonist -
Description
Novel, potent TRPV4 channel agonist -
Alternative names
- GSK1016790A
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Biological description
Novel, potent TRPV4 channel agonist. Induced Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. 300-fold more potent than 4α-PDD.
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CAS Number
942206-85-1 -
Chemical structure
Properties
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Molecular weight
655.61 -
Molecular formula
C28H32Cl2N4O6S2 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(c(Cl)c1)S(=O)(=O)N[C@@H](CO)C(=O)N2CCN(CC2)C(=O)[C@H](CC(C)C)NC(=O)c3cc4ccccc4s3 -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab146191 has been referenced in 1 publication.
- Sinha S et al. Dynamically Crosslinked Poly(ethylene-glycol) Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D. Adv Healthc Mater 12:e2202147 (2023). PubMed: 36239185