GSK 2801, BAZ2 family inhibitor (ab219399)

Overview

  • Product name
    GSK 2801, BAZ2 family inhibitor
  • Description
    Cell-permeable, selective BAZ2 family inhibitor
  • Alternative names
    • GSK2801
  • Biological description

    Cell-permeable, selective, acetyl-lysine competitive inhibitor of the BAZ2 family of bromodomain containing proteins (IC50 values are 0.40 and 0.43 μM for BAZ2A and BAZ2B respectively). Binds to BAZ2 bromodomains with dissociation constants (Kd) of 136 and 257 nM for BAZ2B and BAZ2A, respectively.

  • Purity
    > 98%
  • CAS Number
    1619994-68-1
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone
  • Molecular weight
    371.45
  • Molecular formula
    C20H21NO4S
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 50 mM and in ethanol to 10 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC(C1=CC(C2=CC=CC=C2S(=O)(C)=O)=C3C=C(OCCC)C=CN13)=O
  • Source

    Synthetic

References

This product has been referenced in:
  • Chen P  et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem 59:1410-24 (2016). Read more (PubMed: 25799074) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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