GSK-3beta Inhibitor VII (4-Bromophenacyl bromide), GSK-3beta inhibitor (ab145937)

Overview

  • Product name

    GSK-3beta Inhibitor VII (4-Bromophenacyl bromide), GSK-3beta inhibitor
  • Description

    Cell-permeable, non-ATP competitive GSK-3β inhibitor. Phospholipase A2 inhibitor.
  • Alternative names

    • 4-Bromophenacyl bromide
  • Biological description

    Cell-permeable, non-ATP competitive GSK-3β inhibitor (IC50 = 0.5 µM). Phospholipase A2 inhibitor. Inhibits prostaglandin D2 synthesis from arachidonic acid.
  • Purity

    > 95%
  • CAS Number

    99-73-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Enomoto A  et al. Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death. Free Radic Biol Med 52:507-15 (2012). Read more (PubMed: 22142472) »
  • Conde S  et al. Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching. J Med Chem 46:4631-3 (2003). Read more (PubMed: 14561081) »
  • Ogata Y  et al. 4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts. Comp Biochem Physiol C Toxicol Pharmacol 131:315-22 (2002). Read more (PubMed: 11912056) »
  • Dieter P  et al. 4-Bromophenacyl bromide inhibits prostaglandin D2 synthesis from arachidonic acid rather than phospholipase A2 activity in liver macrophages. Biol Chem Hoppe Seyler 370:543-7 (1989). Read more (PubMed: 2775481) »

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