GSK-690693 hydrochloride, ATP-competitive pan-Akt kinase inhibitor (ab219869)

Overview

  • Product name

    GSK-690693 hydrochloride, ATP-competitive pan-Akt kinase inhibitor
  • Description

    Novel ATP-competitive pan-Akt kinase inhibitor
  • Alternative names

    • GSK 690693 Hydrochloride
    • GSK-690693 HCl
    • GSK690693 hydrochloride
  • Biological description

    Novel ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). Also exhibits some inhibition of AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

  • Purity

    > 99%
  • CAS Number

    937174-76-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridine-4-yl)-2-methylbut-3-yn-2-ol hydrochloride
  • Molecular weight

    461.96
  • Molecular formula

    C21H27N7O3.HCl
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 20 mM and in ethanol to 60 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Nc4nonc4c1nc3c(n1CC)c(OC[C@@H]2CCCNC2)cnc3C#CC(C)(C)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Crouthamel MC  et al. Mechanism and management of AKT inhibitor-induced hyperglycemia. Clin Cancer Res 15:217-25 (2009). Read more (PubMed: 19118049) »
  • Heerding DA  et al. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem 51:5663-79 (2008). Read more (PubMed: 18800763) »
  • Rhodes N  et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res 68:2366-74 (2008). Read more (PubMed: 18381444) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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