Overview

  • Product name

    GSK-J4, histone demethylase JMJD3/UTX inhibitor
  • Description

    Cell permeable histone demethylase JMJD3/UTX inhibitor
  • Alternative names

    • Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
  • Biological description

    Cell permeable histone demethylase JMJD3/UTX inhibitor. Attenuates LPS-induced proinflammatory cytokine production in macrophages (IC50 = 9 μM, TNF-α release). Prodrug of GSK-J1. Rapidly hydrolyzes to GSK-J1 intracellularly.

  • Purity

    > 99%
  • CAS Number

    1373423-53-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kruidenier L  et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488:404-8 (2012). Read more (PubMed: 22842901) »
See 1 Publication for this product

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