Overview

  • Product name
    GSK429286A
  • Description
    Selective ROCK1 and ROCK2 inhibitor
  • Biological description
    Selective ROCK1 and ROCK2 inhibitor. Demonstrated inhibition of ROCKs at 140 nM. Reduces ROCK2 activity over 20-fold at 1 μM. Active in vitro.
  • Purity
    > 98%

Properties

  • Chemical name
    4-[4-(Trifluoromethyl)phenyl]-N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide
  • Molecular weight
    432.37
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C21H16F4N4O2
  • CAS Number
    864082-47-3
  • PubChem identifier
    11373846
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F
  • Source

    Synthetic

References

This product has been referenced in:
  • Sharon-Friling R & Shenk T Human cytomegalovirus pUL37x1-induced calcium flux activates PKCa, inducing altered cell shape and accumulation of cytoplasmic vesicles. Proc Natl Acad Sci U S A 111:E1140-8 (2014). Read more (PubMed: 24616524) »
  • Nichols RJ  et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J 424:47-60 (2009). Read more (PubMed: 19740074) »
  • Goodman KB  et al. Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors. J Med Chem 50:6-9 (2007). Read more (PubMed: 17201405) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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