Overview

  • Product name

    GSK484, PAD4 inhibitor
  • Description

    Potent, reversible inhibitor of PAD4
  • Biological description

    Potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC50 = 50 nM). Selective for PAD4 over PAD1-3. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is re-ordered to form a β-hairpin.  It blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. 

  • Purity

    > 98%
  • General notes

    Protect from air and moisture.

  • CAS Number

    1652591-81-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    ((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
  • Molecular weight

    510.03
  • Molecular formula

    C27H31N5O3.HCl
  • PubChem identifier

    86340151
  • Storage instructions

    Shipped at 4°C. Store at -20°C or -80°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C2=C(C=C(C=C2OC)C(=O)N3CC[C@H]([C@H](C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl
  • Source

    Synthetic

References

ab223598 has not yet been referenced specifically in any publications.

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