GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
Key features and details
- Mechanosensitive and stretch-activated ion channel inhibitor
- CAS Number: 1209500-46-8
Soluble in water to 1mg/ml
- Form / State: Solid
- Source: Grammostola rosea
Overview
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Product name
GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor -
Description
Mechanosensitive and stretch-activated ion channel inhibitor -
CAS Number
1209500-46-8 -
Chemical structure
Properties
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Molecular weight
4095.85 -
Molecular formula
C185H273N49O45S6 -
Sequence
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)
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PubChem identifier
90488987 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 1mg/ml
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Grammostola rosea
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Research areas
Images
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Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
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Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (13)
ab141871 has been referenced in 13 publications.
- Zhu B et al. Piezo 1 activation facilitates cholangiocarcinoma metastasis via Hippo/YAP signaling axis. Mol Ther Nucleic Acids 24:241-252 (2021). PubMed: 33767919
- Hendrickx G et al. Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation. J Bone Miner Res 36:369-384 (2021). PubMed: 33180356
- Kulkarni S et al. Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells. Elife 10:N/A (2021). PubMed: 34184636
- Andolfo I et al. Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway. Am J Hematol 95:188-197 (2020). PubMed: 31737919
- Shen Y et al. The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction. Mol Med Rep 21:2113-2122 (2020). PubMed: 32323761
