GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)

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Overview

  • Product name
    GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
  • Description
    Mechanosensitive and stretch-activated ion channel inhibitor
  • Biological description
    Mechanosensitive and stretch-activated ion channel inhibitor. Acts as a gating modifier for TRPC1 and TRPC6 channels. Interacts with lipid membranes. Blocks atrial fibrillation (IC50 = 1.7 μM). Shows analgesic effects in vivo.

Properties

  • Chemical name

    GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)

  • Molecular weight
    4095.85
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C185H273N49O45S6
  • CAS Number
    1209500-46-8
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 1mg/ml

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Grammostola rosea

  • Research areas

Images

  • Functional Studies - GsMTx-4 (ab141871)
    Functional Studies - GsMTx-4 (ab141871)

    GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.

References

This product has been referenced in:
  • Chen R & Chung SH Effect of gating modifier toxins on membrane thickness: implications for toxin effect on gramicidin and mechanosensitive channels. Toxins (Basel) 5:456-71 (2013). Read more (PubMed: 23435154) »
  • Park SP  et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain 137:208-17 (2008). Read more (PubMed: 18359568) »
  • Bowman CL  et al. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon 49:249-70 (2007). Read more (PubMed: 17157345) »
  • Jung HJ  et al. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun 340:633-8 (2006). Read more (PubMed: 16376854) »
See all 4 Publications for this product

Publishing research using ab141871? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Good solubility, consistency of results across experiments

 Excellent
Abreviews
GsMTx4 used as mechanosensitive channel blocker (concentration range used 500nM-3uM). Gave consistent results across experiments and it was efficent

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Verified customer

Submitted Aug 01 2018

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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