- References (4)
Product nameGsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
DescriptionMechanosensitive and stretch-activated ion channel inhibitor
Biological descriptionMechanosensitive and stretch-activated ion channel inhibitor. Acts as a gating modifier for TRPC1 and TRPC6 channels. Interacts with lipid membranes. Blocks atrial fibrillation (IC50 = 1.7 μM). Shows analgesic effects in vivo.
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 1mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.
This product has been referenced in:
- Chen R & Chung SH Effect of gating modifier toxins on membrane thickness: implications for toxin effect on gramicidin and mechanosensitive channels. Toxins (Basel) 5:456-71 (2013). Read more (PubMed: 23435154) »
- Park SP et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain 137:208-17 (2008). Read more (PubMed: 18359568) »
- Bowman CL et al. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon 49:249-70 (2007). Read more (PubMed: 17157345) »
- Jung HJ et al. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun 340:633-8 (2006). Read more (PubMed: 16376854) »