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    gsmtx-4-mechanosensitive-and-stretch-activated-ion-channel-inhibitor-ab141871.pdf

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GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)

  • Datasheet
  • COA
Reviews (1) Submit a question References (18)

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Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
  • Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)

Key features and details

  • Mechanosensitive and stretch-activated ion channel inhibitor
  • CAS Number: 1209500-46-8
  • Soluble in water to 1mg/ml

  • Form / State: Solid
  • Source: Grammostola rosea

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Overview

  • Product name

    GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
  • Description

    Mechanosensitive and stretch-activated ion channel inhibitor
  • CAS Number

    1209500-46-8
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    4095.85
  • Molecular formula

    C185H273N49O45S6
  • Sequence

    GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)

  • PubChem identifier

    90488987
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 1mg/ml

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Grammostola rosea

  • Research areas

    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals

Images

  • Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
    Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
    2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
  • Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
    Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)

    GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download
  • COA

References (18)

Publishing research using ab141871? Please let us know so that we can cite the reference in this datasheet.

ab141871 has been referenced in 18 publications.

  • Luo M  et al. Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation. BMC Mol Cell Biol 23:1 (2022). PubMed: 34979904
  • Yang Q  et al. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nat Cell Biol 23:733-744 (2021). PubMed: 34155381
  • Lim J  et al. ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10:N/A (2021). PubMed: 34569932
  • Canales Coutiño B & Mayor R The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration. Development 148:N/A (2021). PubMed: 34822717
  • Zhu B  et al. Piezo 1 activation facilitates cholangiocarcinoma metastasis via Hippo/YAP signaling axis. Mol Ther Nucleic Acids 24:241-252 (2021). PubMed: 33767919
View all Publications for this product

Customer reviews and Q&As

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Good solubility, consistency of results across experiments

Excellent
Abreviews
Abreviews
GsMTx4 used as mechanosensitive channel blocker (concentration range used 500nM-3uM). Gave consistent results across experiments and it was efficent
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

Submitted Aug 01 2018

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