GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)
Key features and details
- Mechanosensitive and stretch-activated ion channel inhibitor
- CAS Number: 1209500-46-8
Soluble in water to 1mg/ml
- Form / State: Solid
- Source: Grammostola rosea
Overview
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Product name
GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor -
Description
Mechanosensitive and stretch-activated ion channel inhibitor -
CAS Number
1209500-46-8 -
Chemical structure
Properties
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Molecular weight
4095.85 -
Molecular formula
C185H273N49O45S6 -
Sequence
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30)
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PubChem identifier
90488987 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 1mg/ml
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Grammostola rosea
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Research areas
Images
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Chemical Structure - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)2D chemical structure image of ab141871, GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor
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Functional Studies - GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (ab141871)GsMTx-4 (ab141870) inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 seconds using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141870). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (18)
ab141871 has been referenced in 18 publications.
- Luo M et al. Compression enhances invasive phenotype and matrix degradation of breast Cancer cells via Piezo1 activation. BMC Mol Cell Biol 23:1 (2022). PubMed: 34979904
- Yang Q et al. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nat Cell Biol 23:733-744 (2021). PubMed: 34155381
- Lim J et al. ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10:N/A (2021). PubMed: 34569932
- Canales Coutiño B & Mayor R The mechanosensitive channel Piezo1 cooperates with semaphorins to control neural crest migration. Development 148:N/A (2021). PubMed: 34822717
- Zhu B et al. Piezo 1 activation facilitates cholangiocarcinoma metastasis via Hippo/YAP signaling axis. Mol Ther Nucleic Acids 24:241-252 (2021). PubMed: 33767919
