Guanabenz acetate, alpha 2 adrenoceptor agonist (ab145753)

Overview

  • Product name

    Guanabenz acetate, alpha 2 adrenoceptor agonist
  • Description

    Centrally acting, selective alpha 2 adrenoceptor agonist
  • Alternative names

    • [(2,6-Dichlorobenzylidene)amino]guanidine acetate
    • 1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt
    • Acetate, Guanabenz
    • Guanabenz (Acetate)
    • Guanabenz Monoacetate
    • WY-8678
    • WY-8678 acetate
    see all
  • Biological description

    Centrally acting, selective alpha 2 adrenoceptor agonist. I2 imidazoline binding site selective ligand. Antihypertensive.

  • CAS Number

    23256-50-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(2,6-Dichlorophenyl)methylene]hydrazinecarboximidamide acetate
  • Molecular weight

    291.13
  • Molecular formula

    C8H8Cl2N4.C2H4O2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Tribouillard-Tanvier D  et al. Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One 3:e1981 (2008). Read more (PubMed: 18431471) »
  • Jasper JR  et al. Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol 55:1035-43 (1998). Read more (PubMed: 9605427) »
  • Holmes B  et al. Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs 26:212-29 (1983). Read more (PubMed: 6352237) »
  • Baum T  et al. General pharmacologic actions of the antihypertensive agent 2,6-dichlorobenzylidene aminoguanidine acetate (WY-8678). J Pharmacol Exp Ther 171:276-87 (1970). Read more (PubMed: 5466490) »

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