Key features and details
- Specific Kv2.1 channel blocker
- CAS Number:
- Purity: > 98%
- Soluble in water
- Form / State: Solid
- Source: Plesiophrictus guangxiensis
Product nameGuangxitoxin-1E, Specific Kv2.1 channel blocker
DescriptionSpecific Kv2.1 channel blocker
Biological descriptionSpecific Kv2.1 channel blocker. Stimulates insulin secretion in vitro.
SequenceEGECGGFWWKCGSGKPACCPKYVCSPKWGLCNFPMP (Modifications: Disulfide bonds: 4-19, 11-24, 18-31)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
2D chemical structure image of ab141872, Guangxitoxin-1E, Specific Kv2.1 channel blocker
Guangxitoxin-1E inhibits KV2.1 channel currents expressed in Xenopus oocytes.
Currents were elicited by application of voltage ramp from a holding potential of -80 mV to 60 mV in 100 msec, delivered every 10 seconds. A. Time course of channel activity (current amplitude at +40 mV), before (black) and during (green) application of 100 nM Guangxitoxin-1E (ab141872). B. Top, illustration of the voltage ramp protocol. Bottom, example of superimposed current traces before (black) and during (green) application of 100 nM Guangxitoxin-1E, taken from the experiment in A.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141872 has not yet been referenced specifically in any publications.