Overview

  • Product name

    Guanosine, Purine nucleoside
  • Description

    Purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond
  • Alternative names

    • Guanine riboside
  • Biological description

    Purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). Neuroprotective agent against glutamatergic excitotoxicity by increasing glutamate uptake and decreasing its release.

  • Purity

    > 99%
  • CAS Number

    118-00-3
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    283.24
  • Molecular formula

    C10H13N5O5
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Bettio LE  et al. Guanosine and its role in neuropathologies. Purinergic Signal N/A:N/A (2016). Read more (PubMed: 27002712) »
  • Dal-Cim T  et al. Neuroprotection Promoted by Guanosine Depends on Glutamine Synthetase and Glutamate Transporters Activity in Hippocampal Slices Subjected to Oxygen/Glucose Deprivation. Neurotox Res 29:460-8 (2016). Read more (PubMed: 26858177) »
  • Cittolin-Santos GF  et al. Guanosine Exerts Neuroprotective Effect in an Experimental Model of Acute Ammonia Intoxication. Mol Neurobiol N/A:N/A (2016). Read more (PubMed: 27052954) »
  • Kovacs Z  et al. Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature. Mini Rev Med Chem 14:1033-42 (2015). Read more (PubMed: 25382017) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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