Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist (ab143497)

Overview

  • Product name

    Guggulsterone (pregna-4,17-diene-3,16-dione), steroid receptor antagonist
  • Description

    Broad spectrum steroid receptor antagonist
  • Biological description

    Broad spectrum steroid receptor antagonist (Ki values are 39, 224 and 240 nM for mineralocorticoid, glucocorticoid and androgen receptors respectively). Partial progesterone receptor agonist (Ki = 201 nM). Shows hypoglycemic and hypolipidemic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    95975-55-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Almazari I  et al. Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target. Carcinogenesis 33:368-76 (2012). Read more (PubMed: 22095074) »
  • Sharma B  et al. Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol 47:2631-9 (2009). Read more (PubMed: 19635521) »
  • Chander R  et al. Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study. Indian J Clin Biochem 18:71-9 (2003). Read more (PubMed: 23105395) »

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