Key features and details
- Goat polyclonal to GULP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab2751 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at a concentration of 5 µg/ml.
Western Blot: Preliminary experiments gave an approx 35kDa band in K562 lysates at 1µg/ml. However, this was accompanied by stronger bands at approx 45kDa and 48kDa. Please note that currently we cannot find an explanation in the literature for these extra bands given the predicted size of approx. 35kDda according to NP_057399.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionMay function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Tissue specificityWidely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
Sequence similaritiesBelongs to the ced-6 family.
Contains 1 PID domain.
Cellular localizationCytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.
- Information by UniProt
- CED6 antibody
- Cell death protein 6 homolog antibody
- Engulfment adapter protein antibody
ab2751 has been referenced in 1 publication.
- Bae DJ et al. ArhGAP12 plays dual roles in Stabilin-2 mediated efferocytosis: Regulates Rac1 basal activity and spatiotemporally turns off the Rac1 to orchestrate phagosome maturation. Biochim Biophys Acta Mol Cell Res 1866:1595-1607 (2019). PubMed: 31301364