Overview

  • Product name

    GW 2580, cFMS RTK inhibitor
  • Description

    Selective cFMS RTK inhibitor. Cell-permeable.
  • Biological description

    Selective cFMS (colony stimulating factor 1) RTK inhibitor. Inhibits monocyte growth in vitro (IC50 = 0.2 μM) and LPS-induced TNF-α production in vivo. Inhibits macrophage infiltration of the CNS. Orally active. Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    870483-87-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Crespo O  et al. Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis. J Clin Immunol 31:1010-20 (2011). Read more (PubMed: 21847523) »
  • Conway JG  et al. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther 326:41-50 (2008). Read more (PubMed: 18434589) »
  • Conway JG  et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A 102:16078-83 (2005). Read more (PubMed: 16249345) »
See 1 Publication for this product

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