Overview

  • Product name

    GW 3965 hydrochloride, LXR agonist
  • Description

    Potent and selective LXR agonist
  • Biological description

    Potent and selective LXR agonist (EC50 values are 190 and 30 nM at hLXRα and hLXRβ, respectively). Reduces Ang II-mediated vasopressor responses in rats. Orally active. Anti-inflammatory, Hypolipidemic and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    405911-17-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride
  • Molecular weight

    618.52
  • Molecular formula

    C33H31ClF3NO3.HCl
  • PubChem identifier

    16078973
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Clc4c(cccc4CN(CCCOc1cc(CC(=O)O)ccc1)CC(c2ccccc2)c3ccccc3)C(F)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Guo D  et al. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov 1:442-56 (2011). Read more (PubMed: 22059152) »
  • Scholz H  et al. The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. Diabetologia 52:1352-62 (2009). Read more (PubMed: 19415233) »
  • Leik CE  et al. GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. Br J Pharmacol 151:450-6 (2007). Read more (PubMed: 17420776) »
  • Collins JL  et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45:1963-6 (2002). Read more (PubMed: 11985463) »
See 1 Publication for this product

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