GW 590735, PPARalpha agonist (ab144443)
- Datasheet
- References
Overview
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Product name
GW 590735, PPARalpha agonist -
Description
Potent, selective PPARα agonist -
Biological description
Potent, selective PPARα agonist (EC50 = 4 nM). Increases HDL cholesterol, decreases LDL and VLDL cholesterol. Reduces triglycerides. Shows antidyslipidemic effects in vivo. -
Purity
> 98% -
CAS Number
622402-22-6 -
Chemical structure
Properties
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Chemical name
2-Methyl-2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxamido]methyl]phenoxy]propanoic acid -
Molecular weight
478.48 -
Molecular formula
C23H21F3N2O4S -
PubChem identifier
9956726 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NCC3=CC=C(C=C3)OC(C)(C)C(=O)O -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Velkov T et al. Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain. Protein Expr Purif 70:260-9 (2010). Read more (PubMed: 19782138) »
- Hansen MK et al. Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic mice. J Cardiovasc Pharmacol Ther 15:196-202 (2010). Read more (PubMed: 20332533) »
- Sierra ML et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50:685-95 (2007). Read more (PubMed: 17243659) »
