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    gw-590735-pparalpha-agonist-ab144443.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger
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GW 590735, PPARalpha agonist (ab144443)

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Key features and details

  • Potent, selective PPARα agonist
  • CAS Number: 622402-22-6
  • Purity: > 98%
  • Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    GW 590735, PPARalpha agonist
  • Description

    Potent, selective PPARα agonist
  • Biological description

    Potent, selective PPARα agonist (EC50 = 4 nM). Increases HDL cholesterol, decreases LDL and VLDL cholesterol. Reduces triglycerides. Shows antidyslipidemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    622402-22-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Methyl-2-[4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxamido]methyl]phenoxy]propanoic acid
  • Molecular weight

    478.48
  • Molecular formula

    C23H21F3N2O4S
  • PubChem identifier

    9956726
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NCC3=CC=C(C=C3)OC(C)(C)C(=O)O
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Cancer
    • Signal transduction
    • Nuclear signaling
    • Nuclear hormone receptors
    • Other
    • Cardiovascular
    • Heart
    • Cardiac metabolism
    • Cardiovascular
    • Lipids / Lipoproteins
    • Fatty Acids
    • Metabolism
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Cancer
    • Cancer Metabolism
    • Response to hypoxia
    • Kits/ Lysates/ Other
    • Kits
    • Cell Metabolism Kits
    • Lipid Metabolism Kits
    • Fatty acids
    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Nuclear Receptors
    • PPAR
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitochondrial Biogenesis
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Nucleotide metabolism
    • Molecular processes
    • Mitochondrial transcription
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Fatty acids
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Hypoxia
    • Metabolism
    • Types of disease
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    • Biochemicals
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    • Signaling
    • Lipid signaling
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    • Metabolism
    • Pathways and Processes
    • Redox metabolism
    • Fatty acid oxidation

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab144443? Please let us know so that we can cite the reference in this datasheet.

    ab144443 has not yet been referenced specifically in any publications.

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