Overview

  • Product name

    GW 9508, FFA1 receptor agonist
  • Description

    Potent, selective FFA1 receptor agonist
  • Biological description

    Potent, selective FFA1 receptor agonist (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 respectively). CCL5, CCL17, and CXCL10 induction. Shows anti-inflammatory effects. Shows antihyperglycemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    885101-89-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Moran BM  et al. Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic ß-cells. Diabetes Obes Metab 16:1128-39 (2014). Read more (PubMed: 24919766) »
  • Ou HY  et al. Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity. Am J Physiol Endocrinol Metab 304:E668-76 (2013). Read more (PubMed: 23341496) »
  • Fujita T  et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol 131:1660-7 (2011). Read more (PubMed: 21593768) »

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