Overview

  • Product name

    GW 9662-d5, PPARgamma antagonist
  • Description

    Potent, irreversible and selective PPARγ antagonist
  • Biological description

    Potent, irreversible and selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM at PPARγ, PPARα and PPARβ respectively). Anti-inflammatory and anticancer effects in vitro. Active in vivo.
  • Purity

    > 99%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mehta RG  et al. PPAR? antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance. Mol Cell Biochem 372:249-56 (2013). Read more (PubMed: 23001870) »
  • Seargent JM  et al. GW9662, a potent antagonist of PPARgamma, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation. Br J Pharmacol 143:933-7 (2004). Read more (PubMed: 15533890) »
  • Leesnitzer LM  et al. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry 41:6640-50 (2002). Read more (PubMed: 12022867) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab141261.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up